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Digestive Diseases and Sciences

, Volume 44, Issue 1, pp 14–19 | Cite as

Bile Acid Malabsorption as a Cause of Chronic Diarrhea Diagnostic Value of 7α-Hydroxy-4-Cholesten-3-One in Serum

  • Gerd H. Sauter
  • Wolfgang Munzing
  • Christoph Von Ritter
  • Gustav Paumgartner
Article

Abstract

To evaluate the usefulness of7α-hydroxy-4-cholesten-3-one (HCO) serumconcentrations as a diagnostic marker of bile acidmalabsorption, we determined the reference range of HCOin 106 normal subjects (age 40.2 ± 16.8 years; 55 women, 51men) and conducted a utility study in 23 patients withchronic diarrhea of unknown origin (age 49.4 ±15.3 years, 13 women, 10 men). The diagnosis of bileacid malabsorption was made on the basis of a decreased retentionof [75Se]homocholyltaurine after oralapplication (75SeHCAT test). HCO (referencerange: 6-48 ng/ml) and the 75SeHCAT testyielded the same results in 19/23 (83%) patients. Bile acid malabsorption wasidentified by an increase of HCO in serum with asensitivity of 90% and a specificity of 79%. Analysis ofHCO in serum may serve as a novel, simple, and sensitive method for the detection of bile acidmalabsorption in patients with chronic diarrhea ofunknown origin.

CHOLESTENONES DIAGNOSTIC MARKER BILE ACIDS BILE SALTS ENTEROHEPATIC CIRCULATION DIARRHEA 

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Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Gerd H. Sauter
  • Wolfgang Munzing
  • Christoph Von Ritter
  • Gustav Paumgartner

There are no affiliations available

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