Digestive Diseases and Sciences

, Volume 44, Issue 6, pp 1083–1089 | Cite as

Intragastric Capsaicin Stimulates Motility of Upper Gut and Proximal Colon via Distinct Pathways in Conscious Dogs

  • Chikashi Shibata
  • Iwao Sasaki
  • Hiroo Naito
  • Tatsuya Ueno
  • Seiki Matsuno


The aim of the present study was to investigatethe effect and mechanism of action of intragastric andintraduodenal capsaicin on gastrointestinal motility.Five mongrel dogs were equipped with eight strain gauge force transducers on the stomach, smallintestine, and proximal colon. In the interdigestivestate, capsaicin was administered into the gastric orduodenal lumen. The effects of atropine, hexamethonium, ondansetron, and FK888 on capsaicin-inducedcontractions were studied. Intragastric capsaicininduced contractions within 15 min in the gastricantrum, duodenum, proximal jejunum, and proximal colon.These stimulatory effects were inhibited by atropineat all sites; by hexamethonium in the small intestineand colon; by ondansetron in the antrum, duodenum, andcolon; and by FK888 in the antrum and colon,respectively. Intraduodenal capsaicin had no effect oncontractility. Stimulation of afferent fibers bycapsaicin in the stomach but not in the duodenumaugments contractile activity in local and distantregions of the gut via distinct pathways.



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© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Chikashi Shibata
  • Iwao Sasaki
  • Hiroo Naito
  • Tatsuya Ueno
  • Seiki Matsuno

There are no affiliations available

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