Digestive Diseases and Sciences

, Volume 43, Issue 12, pp 2634–2640

Significance of Angiogenic Factors in Liver Metastatic Tumors Originating from Colorectal Cancers

  • Atsushi Nanashima
  • Masahiro Ito
  • Ichiro Sekine
  • Shinji Naito
  • Hiroyuki Yamaguchi
  • Tohru Nakagoe
  • Hiroyoshi Ayabe
Article

DOI: 10.1023/A:1026643009152

Cite this article as:
Nanashima, A., Ito, M., Sekine, I. et al. Dig Dis Sci (1998) 43: 2634. doi:10.1023/A:1026643009152

Abstract

We examined the expression of vascularendothelial growth factor (VEGF) and microvessel countsexpressed by CD34 staining in 39 patients with primaryand 44 patients with metastatic liver tumors ofmetastatic colorectal carcinoma, and 29 patients withnonmetastatic colorectal carcinoma as control in orderto determine their value in the evaluation of prognosisand recurrence after hepatectomy. Microvessel counts in primary colorectal carcinomas of themetastatic group were significantly higher than those incontrol (P < 0.05). Neither factor correlated withany clinicopathological feature of primary or metastatic liver carcinomas. Higher microvessel counts inmetastatic liver tumors tended to be associated with ashorter disease-free interval to second recurrence inthe remaining liver (P = 0.069) and were significantly associated with poor prognosis afterhepatectomy (P < 0.05). We conclude that microvesselcount is an important marker of liver metastatasis andprognosis in patients with colorectal carcinoma treated with hepatectomy.

VASCULAR ENDOTHELIAL GROWTH FACTOR CD34 LIVER METASTASIS COLORECTAL CARCINOMAS 

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Atsushi Nanashima
  • Masahiro Ito
  • Ichiro Sekine
  • Shinji Naito
  • Hiroyuki Yamaguchi
  • Tohru Nakagoe
  • Hiroyoshi Ayabe

There are no affiliations available

Personalised recommendations