Significance of Angiogenic Factors in Liver Metastatic Tumors Originating from Colorectal Cancers
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- Nanashima, A., Ito, M., Sekine, I. et al. Dig Dis Sci (1998) 43: 2634. doi:10.1023/A:1026643009152
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We examined the expression of vascularendothelial growth factor (VEGF) and microvessel countsexpressed by CD34 staining in 39 patients with primaryand 44 patients with metastatic liver tumors ofmetastatic colorectal carcinoma, and 29 patients withnonmetastatic colorectal carcinoma as control in orderto determine their value in the evaluation of prognosisand recurrence after hepatectomy. Microvessel counts in primary colorectal carcinomas of themetastatic group were significantly higher than those incontrol (P < 0.05). Neither factor correlated withany clinicopathological feature of primary or metastatic liver carcinomas. Higher microvessel counts inmetastatic liver tumors tended to be associated with ashorter disease-free interval to second recurrence inthe remaining liver (P = 0.069) and were significantly associated with poor prognosis afterhepatectomy (P < 0.05). We conclude that microvesselcount is an important marker of liver metastatasis andprognosis in patients with colorectal carcinoma treated with hepatectomy.