Digestive Diseases and Sciences

, Volume 44, Issue 10, pp 2076–2080 | Cite as

Smoking and Male Gender Rather than CagA Protein Are Associated with Increased Risk for Duodenal Ulcer in Helicobacter pylori-Infected Patients in Taiwan

  • Tseng-Shing Chen
  • Full-Young Chang
  • Shou-Dong Lee


The aim of this study was to examine theseroprevalence of antibody to CagA antigen, as well asother major H. pylori antigens by Western blot in H.pylori-infected subjects with endoscopically normal mucosa (N = 54) and duodenal ulcer (N = 51).The role of the host and environmental factors was alsoevaluated. There was no significant difference in theprevalence of antibodies against the major H. pylori antigens between the two groups. A highprevalence of antibody to CagA was detected in patientswith normal mucosa (93%) and duodenal ulcer (86%).Multivariate analysis shows that male gender (odds ratio= 4.94, 95% CI = 1.39-17.77, P = 0.014) and smoking(odds ratio = 8.89, 95% CI = 2.17-36.48, P = 0.002) wereassociated with duodenal ulcer disease. This studysuggests that smoking and male gender rather than CagA protein are associated with increasedrisk for duodenal ulcer in H. pylori-infected patientsin Taiwan.



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Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Tseng-Shing Chen
  • Full-Young Chang
  • Shou-Dong Lee

There are no affiliations available

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