Digestive Diseases and Sciences

, Volume 44, Issue 3, pp 570–577

Clinical Forms of Human Schistosoma mansoni Infection Are Associated with Differential Activation of T-Cell Subsets and Costimulatory Molecules

  • Olindo Assis Martins-Filho
  • Jose Renan Cunha-Melo
  • Jose Roberto Lambertucci
  • Alda Maria S. Silveira
  • Daniel G. Colley
  • Giovanni Gazzinelli
  • Rodrigo Correa-Oliveira
Article

DOI: 10.1023/A:1026613625391

Cite this article as:
Martins-Filho, O.A., Cunha-Melo, J.R., Lambertucci, J.R. et al. Dig Dis Sci (1999) 44: 570. doi:10.1023/A:1026613625391

Abstract

The current study has compared the activationstatus and the expression of the CD28 molecule oncirculating CD4+ and CD8+lymphocytes from patients with different clinical formsof schistosomiasis. The data show that patients with acuteschistosomiasis have an increase on the mean percentageof CD4+HLA-DR+ cells, whereaschronic asymptomatic patients exhibit an increased meanpercentage of CD8+HLA-DR+ cells. Patients with the hepatosplenic diseaseshowed an increase in bothCD4+HLA-DR+ andCD8+HLA-DR+ cells. Despite thehigh levels of CD8+HLA-DR+ cellsin hepatosplenic patients, they presented a decreased ratio ofCD8+CD28+/CD8+ cells.These findings of a different percentage of circulatingCD8+CD28+ cells might explain thedifferent in vitro cellular reactivity of asymptomaticand hepatosplenic patients and the defects in the cytokine secretionpatterns reported in individuals with hepatosplenicschistosomiasis.

SCHISTOSOMIASIS CLINICAL FORMS T-CELL SUBSETS 

Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Olindo Assis Martins-Filho
  • Jose Renan Cunha-Melo
  • Jose Roberto Lambertucci
  • Alda Maria S. Silveira
  • Daniel G. Colley
  • Giovanni Gazzinelli
  • Rodrigo Correa-Oliveira

There are no affiliations available

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