Psyllium Improves Fecal Consistency and Prevents Enhanced Secretory Responses in Jejunal Tissues of Piglets Infected with ETEC
Infection with enterotoxigenic E. coli (ETEC)induces secretory diarrhea by stimulating net secretionof fluid and electrolytes. We tested the hypothesis thatETEC potentiates jejunal ion secretion induced by other agonists and also examined whether thesoluble fiber psyllium ameliorates effects ofETEC-induced pathophysiology. Noninfected orETEC-infected piglets were given oral electrolytesolution twice daily or electrolyte solution supplemented withpsyllium for 48 hr. Jejunal tissues were mounted in fluxchambers and basal and stimulated ion transportresponses, as reflected by short-circuit current (ISC) were measured. The severity ofETEC-induced diarrhea was reduced by psyllium.ISC responses to carbachol and5-hydroxytryptamine were greater in tissues frominfected piglets compared with noninfected controls or infected piglets given psyllium.These results suggest that psyllium amelioratesETEC-induced diarrhea and prevents the enhancedsecretory responses to calcium-mediated agonists thatoccur in ETEC-infected piglet jejunum.
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