Cancer Causes & Control

, Volume 11, Issue 10, pp 965–974 | Cite as

Diet in the epidemiology of endometrial cancer in Western New York (United States)

  • Susan E. McCann
  • Jo L. Freudenheim
  • James R. Marshall
  • John R. Brasure
  • Mya K. Swanson
  • Saxon Graham
Article

Abstract

Objectives: We examined diet and risk of endometrial cancer among women in the Western New York Diet Study (1986–1991).

Methods: Self-reported frequency of use of 172 foods and beverages during the 2 years before the interview and other relevant data were collected by detailed interviews from 232 endometrial cancer cases and 639 controls, frequency-matched for age and county of residence. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression, adjusting for age, education, body mass index (BMI), smoking history, hypertension, diabetes, age at menarche, parity, oral contraceptive use, menopausal status, menopausal estrogen use, and energy.

Results: Risks were reduced for women in the highest quartiles of intake of protein (OR 0.4, 95% CI: 0.2–0.9), dietary fiber (OR 0.5, 95% CI: 0.3–1.0), phytosterols (OR 0.6, 95% CI: 0.3–1.0), vitamin C (OR 0.5, 95% CI: 0.3–0.8) folate (OR 0.4, 95% CI: 0.2–0.7), alpha-carotene (OR 0.6, 95% CI: 0.4–1.0), beta-carotene (OR 0.4, 95% CI: 0.2–0.6), lycopene (OR 0.6, 95% CI: 0.4–1.0), lutein + zeaxanthin (OR 0.3, 95% CI: 0.2–0.5) and vegetables (OR 0.5, 95% CI: 0.3–0.9), but unrelated to energy (OR 0.9, 95% CI: 0.6–1.5) or fat (OR 1.6, 95% CI: 0.7–3.4).

Conclusions: Our results support previous findings of reduced endometrial cancer risks associated with a diet high in plant foods.

carotenoids diet endometrial neoplasms nutritional epidemiology phytosterols 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    American Institute for Cancer Research (1997) Food, Nutrition and the Prevention of Cancer: a global perspective. Part II: Cancers, nutrition and food, Chapter 4.13: Endometrium. Washington, DC: American Institute for Cancer Research.Google Scholar
  2. 2.
    Thomas HV, Davey GK, Key TJ (1999) Oestradiol and sex hormone-binding globulin in premenopausal and postmenopausal meat-eaters, vegetarians and vegans. Br J Cancer 80: 1470–1475.PubMedGoogle Scholar
  3. 3.
    Boyd NF, Lockwood GA, Greenberg CV, Martin LJ, Tritchler DL (1997) Effects of a low-fat high-carbohydrate diet on plasma sex hormones in premenopausal women: results from a randomized controlled trial. Canadian Diet and Breast Cancer Prevention Study Group. Br J Cancer 76: 127–135.PubMedGoogle Scholar
  4. 4.
    Woods MN, Barnett JB, Spiegelman D, et al. (1996) Hormone levels during dietary changes in premenopausal African-American women. J Natl Cancer Inst 88: 1369–1374.PubMedGoogle Scholar
  5. 5.
    Gates JR, Parpia B, Campbell TC, Junshi C (1996) Association of dietary factors and selected plasma variables with sex hormone-binding globulin in rural Chinese women. Am J Clin Nutr 63: 22–31.PubMedGoogle Scholar
  6. 6.
    Bagga D, Ashley JM, Geffrey SP, et al. (1995) Effects of a very low fat, high fiber diet on serum hormones and menstrual function. Implications for breast cancer prevention. Cancer 76: 2491–2496.PubMedGoogle Scholar
  7. 7.
    Jacques H, Noreau L, Moorjani S (1992) Effects on plasma lipoproteins and endogenous sex hormones of substituting lean white fish for other animal-protein sources in diets of postmeno-pausal women. Am J Clin Nutr 55: 896–901.PubMedGoogle Scholar
  8. 8.
    Bennett FC, Ingram DM (1990) Diet and female sex hormone concentrations: an intervention study for the type of fat consumed. Am J Clin Nutr 52: 808–812.PubMedGoogle Scholar
  9. 9.
    London S, Willett W, Longcope C, McKinlay S (1991) Alcohol and other dietary factors in relation to serum hormone concentrations in women at climacteric. Am J Clin Nutr 53: 166–171.PubMedGoogle Scholar
  10. 10.
    Hill P, Garbaczewski L, Helman P, Huskisson J, Sporangisa E, Wynder EL (1980) Diet, lifestyle, and menstrual activity. Am J Clin Nutr 33: 1192–1198.PubMedGoogle Scholar
  11. 11.
    Bennett FC, Ingram DM (1990) Diet and female sex hormone concentrations: an intervention study for the type of fat consumed. Am J Clin Nutr 52: 808–812.PubMedGoogle Scholar
  12. 12.
    Rose DP, Boyar AP, Cohen C, Strong LE (1987) Effect of a low-fat diet on hormone levels in women with cystic breast disease. I. Serum steroids and gonadotropins. J Natl Cancer Inst 78: 623–626.PubMedGoogle Scholar
  13. 13.
    Shu XO, Zheng W, Potischman N, et al. (1993) A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People's Republic of China. Am J Epidemiol 137: 155–165.PubMedGoogle Scholar
  14. 14.
    Zheng W, Kushi LH, Potter JD, et al. (1995) Dietary intake of energy and animal foods and endometrial cancer incidence. The Iowa women's health study. Am J Epidemiol 142: 388–394.PubMedGoogle Scholar
  15. 15.
    Levi F, Franceschi S, Negri E, La Vecchia C (1993) Dietary factors and the risk of endometrial cancer. Cancer 71: 3575–3581.PubMedGoogle Scholar
  16. 16.
    Potischman N, Swanson CA, Brinton LA, et al. (1993) Dietary associations in a case-control study of endometrial cancer. Cancer Causes Control 4: 239–250.PubMedGoogle Scholar
  17. 17.
    Barbone F, Austin H, Partridge EE (1993) Diet, endometrial cancer: a case-control study. Am J Epidemiol 137: 393–403.PubMedGoogle Scholar
  18. 18.
    Negri E, La Vecchia C, Franceschi S, Levi F, Parazzini F (1996) Intake of selected micronutrients and the risk of endometrial carcinoma. Cancer 77: 917–923.PubMedGoogle Scholar
  19. 19.
    Goodman MT, Nomura AMY, Kolonel LN, Hankin JH (1994) Case-control study of the effect of diet, body size on the risk of endometrial cancer. In: Rao RS, Deo MA, Sanghvi DA, eds. Proceedings of the International Cancer Congress. New Delhi: Monduzzi Editore.Google Scholar
  20. 20.
    La Vecchia C, DeCarli A, Fasoli M, Gentile A (1986) Nutrition and diet in the etiology of endometrial cancer. Cancer 57: 1248–1253.PubMedGoogle Scholar
  21. 21.
    Graham S, Hellmann R, Marshall J, et al. (1991) Nutritional epidemiology of postmenopausal breast cancer in Western New York. Am J Epidemiol 134: 552–566.PubMedGoogle Scholar
  22. 22.
    Freudenheim JL, Marshall JR, Vena JE, et al. (1996) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients. J Natl Cancer Inst 88: 340–348.PubMedGoogle Scholar
  23. 23.
    US Department of Agriculture (1976–1989) Composition of Foods. Washington, DC: US Government Printing Office (Agriculture Handbook 8, revisions 8._1–8._17, 8._21).Google Scholar
  24. 24.
    US Department of Agriculture (1975) Nutritive Value of American Foods in Common Units. Washington, DC: US Government Printing Office (Agriculture Handbook 456).Google Scholar
  25. 25.
    Mangels AR, Holden JM, Beecher GR, Forman MR, Lanza E (1993) Carotenoid content of fruits and vegetables: an evaluation of analytic data [published erratum appears in J Am Diet Assoc 93: 527]. J Am Diet Assoc 93: 284–296.PubMedGoogle Scholar
  26. 26.
    Chug-Ahuja JK, Holden JM, Forman MR, Mangels AR, Beecher GR, Lanza E (1993) The development and application of a carotenoid database for fruits, vegetables, and selected multicomponent foods. J Am Diet Assoc 93: 318–323.PubMedGoogle Scholar
  27. 27.
    Gorbach SL, Goldin BR (1987) Diet and the excretion and enterohepatic cycling of estrogens. Prev Med 16: 515–531.Google Scholar
  28. 28.
    Lampe JW (1999) Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies. Am J Clin Nutr 70(Suppl.): 475S-490S.Google Scholar
  29. 29.
    Bailey LB, Gregory JF (1999) Folate metabolism and requirements. J Nutr 129: 779–782.PubMedGoogle Scholar
  30. 30.
    Falette NS, Fuqua SA, Chamness GC, Cheah MS, Greene GL, McGuire WL (1990) Estrogen receptor gene methylation in human breast tumors. Cancer Res 50: 3974–3978.PubMedGoogle Scholar
  31. 31.
    Woods MN, Gorbach SL, Longcope C, Goldin BR, Dwyer JT, Morrill-LaBrode A (1989) Low-fat, high-fiber diet and serum estron sulfate in premenopausal women. Am J Clin Nutr 49: 1179–1183.PubMedGoogle Scholar
  32. 32.
    Ling WH, Jones PJH (1995) Dietary phytosterols: a review of metabolism, benefits and side effects. Life Sci 57: 195–206.PubMedGoogle Scholar
  33. 33.
    Mellanen P, Petane T, Lehtimaki J, et al. (1996) Wood derived estrogens: studies in vitro with breast cancer cell lines and in vivo in trout. Toxical Appl Pharmacol 136: 381–388.Google Scholar

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Susan E. McCann
    • 1
  • Jo L. Freudenheim
    • 1
  • James R. Marshall
    • 2
  • John R. Brasure
    • 1
  • Mya K. Swanson
    • 1
  • Saxon Graham
    • 1
  1. 1.Department of Social and Preventive MedicineState University of New York at BuffaloBuffaloUSA
  2. 2.Arizona Cancer CenterTucsonUSA

Personalised recommendations