Journal of Mammary Gland Biology and Neoplasia

, Volume 2, Issue 1, pp 49–57

Early Mammary Development: Growth Hormone and IGF-1

  • David L. Kleinberg

DOI: 10.1023/A:1026373513521

Cite this article as:
Kleinberg, D.L. J Mammary Gland Biol Neoplasia (1997) 2: 49. doi:10.1023/A:1026373513521


The first step in pubertal mammary development is the appearance of terminal end buds arising from pleuropotent stem cells present in the immature ductal tree of the prepubertal animal. Work from this laboratory indicates that growth hormone is the pituitary hormone responsible for terminal end bud development. Growth hormone likely acts through the production of IGF-1.3 This minireview focuses on the hormonal control of early mammary development with special emphasis on the roles of growth hormone and IGF-1.

Pleuropotent stem cells pubertal mammary development terminal end bud lactogenesis 

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • David L. Kleinberg
    • 1
  1. 1.Department of MedicineNew York University Medical Center, and Department of Veterans Affairs Medical CenterNew York

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