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Cellular and Molecular Neurobiology

, Volume 18, Issue 5, pp 461–475 | Cite as

The Relationship Between Adhesion Molecules and Neuronal Plasticity

  • Keith B. Hoffman
Article

Abstract

1. It is presently widely assumed that structural reorganization of synaptic architectures subserves the functional gains that define certain neuronal plasticities.

2. While target molecules thought to participate in such morphological dynamics are not well defined, growing evidence suggests a pivotal role for cell adhesion molecules.

3. Herein, brief discussions are presented on (i) the history of how adhesion molecules became implicated in plasticity and memory processes, (ii) the general biology of some of the major classes of such molecules, and (iii) the future of the adhesion molecule/plasticity relationship.

neural cell adhesion NCAM L1 integrins synaptic plasticity LTP memory history 

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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Keith B. Hoffman
    • 1
  1. 1.Ancile PharmaceuticalsLa Jolla

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