Journal of Mammary Gland Biology and Neoplasia

, Volume 2, Issue 4, pp 323–334 | Cite as

Mammary Gland Development and Tumorigenesis in Estrogen Receptor Knockout Mice

  • Wayne P. Bocchinfuso
  • Kenneth S. Korach


Estrogens are important for the development of the mammary gland and strongly associated with oncogenesis in this tissue. The biological effects of estrogens are mediated through the estrogen receptor (ER),3 a member of the nuclear receptor superfamily. The estrogen/ER signaling pathway plays a central role in mammary gland development, regulating the expression and activity of other growth factors and their receptors. The generation of the ER knockout (ERKO) mouse has made it possible to directly understand the contribution of ER in mammary development and has provided an unique opportunity to study estrogen action in carcinogenesis. A mammary oncogene (Wnt-1) was introduced into the ERKO background to determine if the absence of the ER would affect the development of tumors induced by oncogenic stimulation. The development, hyperplasia, and tumorigenesis in mammary glands from the ERKO/Wnt-1 mouse line are described. These studies provide the impetus to evaluate the effect of other oncogenes in mammary tumorigenesis in the absence of estrogen/ER signaling.

Wnt-1 breast cancer hyperplasia progesterone prolactin cyclin D1 


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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Wayne P. Bocchinfuso
    • 1
  • Kenneth S. Korach
    • 1
  1. 1.Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle Park

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