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Journal of Assisted Reproduction and Genetics

, Volume 20, Issue 10, pp 395–399 | Cite as

Treatment-Associated Serum FSH Levels in Very Poor Responders to Ovarian Stimulation

  • Peyman Saadat
  • Cristin C. Slater
  • John K. Jain
  • David E. Tourgeman
  • Frank Z. Stanczyk
  • Richard J. Paulson
Article

Abstract

Purpose: To compare treatment-associated follicle-stimulating hormone (FSH) response in patients undergoing controlled ovarian hyperstimulation with either microdose flare (MDF) leuprolide acetate or clomiphene citrate and human menopausal gonadotropin (CC/hMG).

Methods: Thirteen patients who were deemed poor responders underwent stimulation with one of two poor responder stimulation protocols (MDF group: n = 8; CC/hMG group: n = 5). Serum FSH, estrone (E1), estrone sulfate (E1S), and estradiol (E2) levels were measured at baseline, day 5 of medication, and on day of hCG administration. Ovarian and uterine responses were evaluated by ultrasound.

Results: Treatment-associated FSH levels were consistently higher in the group that took CC/hMG. However, serum E1, E1S, and E2 values were similar in both groups as were the number of oocytes retrieved and the endometrial echo complex. There were no differences between the two groups with regards to the quality of the oocytes obtained, fertilization rate, or the quality of the embryos.

Conclusion: Clomiphene citrate, when administered in conjunction with exogenous hMG, is a more potent stimulator of FSH production than MDF leuprolide acetate among poor responders to ovarian stimulation. However, the number of oocytes is not increased.

Clomiphene/hMG in vitro fertilization microdose flare poor responders 

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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Peyman Saadat
    • 1
  • Cristin C. Slater
    • 1
  • John K. Jain
    • 1
  • David E. Tourgeman
    • 1
  • Frank Z. Stanczyk
    • 1
  • Richard J. Paulson
    • 1
  1. 1.Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and GynecologyKeck School of Medicine of the University of Southern CaliforniaLos Angeles

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