Neurochemical Research

, Volume 28, Issue 12, pp 1793–1797 | Cite as

Ketogenic Diet Increases Glutathione Peroxidase Activity in Rat Hippocampus

  • Denize R. Ziegler
  • Leticia C. Ribeiro
  • Martine Hagenn
  • lonara R. Siqueira
  • Emeli Araújo
  • Iracy L. S. Torres
  • Carmem Gottfried
  • Carlos Alexandre Netto
  • Carlos-Alberto Gonçalves
Article

Abstract

Ketogenic diets have been used in the treatment of refractory childhood epilepsy for almost 80 years; however, we know little about the underlying biochemical basis of their action. In this study, we evaluate oxidative stress in different brain regions from Wistar rats fed a ketogenic diet. Cerebral cortex appears to have not been affected by this diet, and cerebellum presented a decrease in antioxidant capacity measured by a luminol oxidation assay without changes in antioxidant enzyme activities—glutathione peroxidase, catalase, and superoxide dismutase. In the hippocampus, however, we observed an increase in antioxidant activity accompanied by an increase of glutathione peroxidase (about 4 times) and no changes in lipoperoxidation levels. We suggest that the higher activity of this enzyme induced by ketogenic diet in hippocampus might contribute to protect this structure from neurodegenerative sequelae of convulsive disorders.

Ketogenic diet oxidative stress glutathione peroxidase lipoperoxidation hippocampus 

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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Denize R. Ziegler
    • 1
  • Leticia C. Ribeiro
    • 2
  • Martine Hagenn
    • 3
  • lonara R. Siqueira
    • 2
  • Emeli Araújo
    • 2
  • Iracy L. S. Torres
    • 2
  • Carmem Gottfried
    • 1
    • 2
  • Carlos Alexandre Netto
    • 2
  • Carlos-Alberto Gonçalves
    • 2
  1. 1.Centro de Ciências da SaúdeUniversidade do Vale do Rio dos SinosSão Leopoldo, RSBrazil
  2. 2.Departamento de Bioquìmica, ICBSUniversidade Federal do Rio Grande do SulPorto Alegre, RSBrazil
  3. 3.Departamento de Fisiologia, ICBSUniversidade Federal do Rio Grande do SulPorto Alegre, RSBrazil

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