Molecular Biology

, Volume 37, Issue 5, pp 707–715 | Cite as

Search for Alternative RNA Secondary Structures Regulating Expression of Bacterial Genes

  • E. V. Lyubetskaya
  • L. A. Leont'ev
  • M. S. Gelfand
  • V. A. Lyubetsky


Expression of many bacterial genes is regulated by formation of alternative secondary RNA structure within the leader mRNA sequence. Our algorithm designed to search for these structures (basing on analysis of one nucleotide sequence) was applied to analyze operons of amino acid biosynthesis in alpha- and gamma-proteobacteria. The attenuators of these operons are predicted for genomes of some poorly known gamma-proteobacteria including Shewanella putrefaciens, attenuators of the tryptophan operon in some alpha-proteobacteria are also predicted.

attenuator structure proteobacteria expression regulation search algorithm 


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Copyright information

© MAIK “Nauka/Interperiodica” 2003

Authors and Affiliations

  • E. V. Lyubetskaya
    • 1
  • L. A. Leont'ev
    • 1
  • M. S. Gelfand
    • 2
  • V. A. Lyubetsky
    • 1
  1. 1.Institute for Information Transmission ProblemsRussian Academy of SciencesMoscowRussia
  2. 2.State Research Center GosNIIGenetikaMoscowRussia

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