Journal of Autism and Developmental Disorders

, Volume 28, Issue 2, pp 105–110

No Difference in Hippocampus Volume Detected on Magnetic Resonance Imaging in Autistic Individuals

  • Joseph Piven
  • James Bailey
  • Bonnie J. Ranson
  • Stephan Arndt


Neuropathological and animal studies have implicated the hippocampus as having a potential role in autism. Current imaging methods are well suited to the detailed measurement of the volume of the hippocampus, which has received little attention in previous imaging studies in autism. We report the results of a magnetic resonance imaging (MRI) study of 35 autistic and 36 control subjects. Detailed (1.5 mm) MRI did not reveal differences in the volume of the hippocampus in autistic individuals.

Hippocampus magnetic resonance imaging autism 


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  1. American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed., Rev.). Washington, DC: Author.Google Scholar
  2. Andreasen, N. C., Rajaprabhakaran, R., & Cizadlo, T. (1994). Automatic atlas-based dissection of human brain from MR images. San Francisco: Society of Magnetic Resonance in Medicine.Google Scholar
  3. Andreasen, N. C., Cohen, G., Harris, G., Cizadlo, T., Parkkinen, J., Rezai, K., & Swayze, V. (1992). Image processing for the study of brain structure and function: Problems and programs. Journal of Neuropsychiatry and Clinical Neuroscience, 4, 125–133.Google Scholar
  4. Andreasen, N. C., Harris, G., Cizadlo, T., Arndt, S., O'Leary, D. S., Swayze, V. W., & Flaum, M. (1994). Techniques for measuring sulcal/gyral patterns in the brain as visualized through MR scanning: BRAINPLOT and BRAINMAP. Proceedings of the National Academy of Sciences of the United States of America, 900, 93–97.Google Scholar
  5. Andreasen, N. C., Rajaprabhakaran, R., Cizadlo, T., Arndt, S., Swayze, V. W., II, Flashman, L. A., O'Leary, D. S., Ehrhardt, J. C., & Yuh, W. C. (1996). Automatic atlas-based volume estimation of human brain regions from MR images. Journal of Computer Assisted Tomography 20, 98–106.Google Scholar
  6. Arndt, S., Swayze, V., Cizadlo, T., O'Leary, D., Cohen, G., Yuh, W. T. C., Ehrhardt, J., & Andreasen, N. C. (1994). Evaluating and validating two methods for estimating brain structure volumes: Tessellation and simple pixel counting. Neuroimage, 1, 191–198.Google Scholar
  7. Arndt, S., Rajarethinam, R., Cizadlo, T, O'Leary, D. S., Downhill, J., & Andreasen, N. C. (1996). Landmark-based MR Image Registration and Measurement: A Reliability Study. Psychiatric Research—Neuroimaging, 67, 145–154.Google Scholar
  8. Arthur, G. (1952). The Arthur Adaptation of the Leiter International Performance Scale. Chicago: Psychological Service Center Press.Google Scholar
  9. Bachevalier, J., & Merjanian, P. M. (1994). The contribution of medial temporal lobe structures in infantile autism: A neurobehavioral study in primates. In M. L. Bauman & T. L. Kemper (Eds.), The neurobiology of autism (pp. 146–169). Baltimore: Johns Hopkins University Press.Google Scholar
  10. Bauman, M. L., & Kemper, T. L. (1994). Neuroanatomic observations of the brain in autism. In M. L. Bauman & T. L. Kemper (Eds.), The neurobiology of autism. Baltimore: Johns Hopkins University Press.Google Scholar
  11. Cizadlo, T., Andreasen, N. C., Zeien, G., Rajaprabhakaran, R., Harris, G., O'Leary, D. S., Swayze, V. W., Arndt, S., Hichwa, R., Ehrhardt, J., & Yuh, W. T. C. (1994). Image registration issues in the analysis of multiple-injection 150H20 PET studies: BRAINFIT. Society Photo-Optical Instrumentation Engineers, International Society for Optical Engineering, 2168, 423–430.Google Scholar
  12. Cohen, G., Andreasen, N. C., Alliger, R., Arndt, S., Kaun, J., Yuh, W. T. C., & Ehrhardt, J. (1992). Segmentation techniques for the classification of brain tissue using magnetic resonance imaging. Psychiatry Research: Neuroimaging, 46, 33–51.Google Scholar
  13. DeLong, R. G. (1992). Autism, amnesia, hippocampus, and learning. Neuroscience & Behavioral Reviews, 16, 63–70.Google Scholar
  14. Filipek, P. A., Richelme, C., Kennedy, C. N., Rademacher, J., Pitcher, D. A., Zidel, S., & Caviness, V. S. (1992). Morphometric analysis of the brain in developmental language disorder and autism. Annals of Neurology, 32, 475. (abstract).Google Scholar
  15. Lainhart, J. E., & Piven, J. (1995). Diagnosis, treatment, and neurobiology of autism in children. Current Opinion in Pediatrics, 4, 392–400.Google Scholar
  16. Le Couteur, A., Rutter, M., Lord, C., Rios, P., Holdgrafer, M., and McLennan, J. (1989). Autism Diagnostic Interview: A standardized investigator-based instrument. Journal of Autism and Developmental Disorders, 19, 363–386.Google Scholar
  17. Piven, J., Arndt, S., Bailey, J., & Andreasen, N. (1996). Regional brain enlargement in autism: A magnetic resonance imaging study. Journal of the American Academy of Child & Adolescent Psychiatry, 35, 530–536.Google Scholar
  18. Piven, J., Nehme, E., Simon, J., Barta, P., Pearlson, G., & Folstein, S. F. (1992). Magnetic resonance imaging in autism: Measurement of the cerebellum, pons, and fourth ventricle. Biological Psychiatry, 31, 491–504.Google Scholar
  19. Rauch, R. A., & Jinkins, J. R. (1996). Variability of corpus callosal area measurements from midsagittal MR images: Effect of subject placement within the scanner. American Journal of Neuroradiology, 17, 27–28.Google Scholar
  20. Saitoh, O., Courchesne, E., Egaas, B., Lincoln, A. J., & Schreibman, L. (1995). Cross-sectional area of the posterior hippocampus in autistic patients with cerebellar and corpus callosum abnormalities. Neurology, 45, 317–324.Google Scholar
  21. Watson, C., Andermann, F., Gloor, P., Jones-Gotman, M., Peters, T., Evans, A., Olivier, A., Melanson, D., & Leroux, G. (1992). Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology, 42, 1743–1750.Google Scholar
  22. Wechsler, D. (1981). Wechsler Adult Intelligence Scale (Rev.). San Antonio, TX: Psychological Corp.Google Scholar
  23. Wechsler, D. (1991). Wechsler Intelligence Scale for Children (3rd ed.). San Antonio, TX: Psychological Corporation.Google Scholar
  24. World Health Organization. (1993). The ICD-10 classification of mental and behavioral disorders. Diagnostic criteria for research. Geneva: Author.Google Scholar

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Joseph Piven
    • 1
    • 2
  • James Bailey
    • 1
  • Bonnie J. Ranson
    • 1
  • Stephan Arndt
    • 1
  1. 1.The Department of PsychiatryUniversity of IowaIowa City
  2. 2.Child and Adolescent Psychiatry ClinicUniversity of Iowa Hospitals and ClinicsIowa City

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