Molecular and Cellular Biochemistry

, Volume 253, Issue 1–2, pp 41–47 | Cite as

Antimicrotubular drugs binding to vinca domain of tubulin

  • Suvroma Gupta
  • Bhabatarak Bhattacharyya


Studies on vinca domain binding drugs were done in great details by a number of workers as it is recognized as a potential target for anticancer drug development. Their structures, properties, mode of action, success and failures as potential anticancer drug have been discussed in short details in this review. Among these drugs rhizoxin and maytansine are competitive inhibitors, and bind at the vinblastine binding site of tubulin where as others are non-competitive inhibitors. Besides binding, these drugs also differ in the extent of GTP hydrolysis, GTP exchange and in the stabilization of colchicine binding site. The toxicity level of these drugs towards the host cells and the extent of efflux of drugs by the P-glycoprotein mediated pump are also discussed.

tubulin microtubules spindle anticancer drugs vinblastine 


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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Suvroma Gupta
    • 1
  • Bhabatarak Bhattacharyya
    • 1
  1. 1.Department of BiochemistryBose InstituteCalcuttaIndia

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