Molecular and Cellular Biochemistry

, Volume 253, Issue 1–2, pp 3–13 | Cite as

Regulation of L-type Ca2+ channels in the heart: Overview of recent advances

  • Kaoru Yamaoka
  • Masaki Kameyama
Article

Abstract

Regulation of L-type Ca2+ channels is complex, because many factors, such as phosphorylation, divalent cations, and proteins, specified or unspecified, have been shown to affect the channel activities. An additional complication is that these factors interact with one another to achieve final outcomes. Recent molecular technologies have helped to shed light on the mechanisms governing the activity of L-type Ca2+ channels. In this review article, three major topics concerning regulation of L-type Ca2+ channels in the heart are discussed, i.e. c-AMP dependent channel phosphorylation, role of magnesium (Mg2+), and the phenomenon of channel run-down.

L-type Ca2+ channel magnesium run-down phosphorylation 

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Kaoru Yamaoka
    • 1
  • Masaki Kameyama
    • 2
  1. 1.Department of Physiology, School of MedicineHiroshima UniversityMinami-Ku, HiroshimaJapan
  2. 2.Department of Physiology, Faculty of MedicineKagoshima UniversitySakura-ga-oka, KagoshimaJapan

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