Cancer and Metastasis Reviews

, Volume 23, Issue 1–2, pp 53–61

TGFβ and Wnt pathway cross-talk

  • Liliana Attisano
  • Etienne Labbé


Transforming growth factor-βs (TGFβ) and Wnts represent two distinct families of secreted molecules each of which utilizes different signaling pathways to elicit their biological effects. These factors regulate numerous developmental events and mutations in components of both pathways have been described in human cancers including colorectal carcinomas. Several studies have demonstrated that TGFβ and Wnt ligands can cooperate to regulate differentiation and cell fate determination by controlling gene expression patterns. In addition, their cooperation in promoting tumorigenesis in mice has been described. Here, we focus on reviewing our current understanding of the molecular mechanisms that may mediate these cooperative effects.

TGFβ Wnt signal transduction smads cancer 


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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Liliana Attisano
    • 1
  • Etienne Labbé
    • 2
  1. 1.Department of Biochemistry and Department of Medical BiophysicsUniversity of TorontoTorontoCanada
  2. 2.Department of Medical BiophysicsUniversity of TorontoTorontoCanada

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