Journal of Neurocytology

, Volume 31, Issue 6–7, pp 481 ppl=–495

Oligodendrocyte precursor cells: Reactive cells that inhibit axon growth and regeneration

  • Zhi Jiang Chen
  • Micheal Negra
  • Angela Levine
  • Yvonne Ughrin
  • Joel M. Levine
Article

DOI: 10.1023/A:1025791614468

Cite this article as:
Chen, Z.J., Negra, M., Levine, A. et al. J Neurocytol (2002) 31: 481 ppl=. doi:10.1023/A:1025791614468

Abstract

Oligodendrocyte precursor cells (OPCs) are a newly recognized glial component of the adult central nervous system of unknown function. Antibodies against the NG2 chondroitin sulfate proteoglycan have been useful tools to identify these cells in intact tissue. Here we review studies that show that OPCs react to several types of experimentally induced brain injury. Injury stimulates OPCs to re-enter the cell cycle, divide, and accumulate at the site of damage. OPCs, together with microglia and astrocytes, form the glial scar. Glial scars are thought to inhibit or prevent axonal regeneration and reactive OPCs contribute to this inhibition by producing growth-inhibiting chondroitin sulfate proteoglycans, particularly NG2. In developing animals, NG2 is found in areas, such as the perinotochordal mesenchyme, that are avoided by growing motor and sensory axons. Within the developing CNS, NG2-expressing cells surround the developing optic chiasm and tract and separate it from the overlying diencephalon. Thus, NG2-expressing cells are well positioned to inhibit axonal growth from developing as well as regenerating neurons.

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Zhi Jiang Chen
    • 1
  • Micheal Negra
    • 1
  • Angela Levine
    • 1
  • Yvonne Ughrin
    • 1
  • Joel M. Levine
    • 1
  1. 1.Department of Neurobiology and BehaviorSUNY at Stony BrookStony BrookUSA

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