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International Urology and Nephrology

, Volume 34, Issue 4, pp 551–553 | Cite as

Tuberculosis in renal transplant recipients: Rifampicin sparing treatment protocol

  • Tushar J. VachharajaniEmail author
  • Umesh G. Oza
  • Ajit G. Phadke
  • Ashok L. Kirpalani
Article

Abstract

The reactivation of mycobacterium infection inrenal transplant recipients in developingcountries is a common therapeutic dilemma,especially in those patients receivingcyclosporin immunosuppression. The inclusion ofrifampicin in the antituberculosis protocolincreases the risk of precipitating acuteallograft rejection due to its interaction withcyclosporin and also increases the financialburden. We successfully treated 16 patients whodeveloped mycobacterial infection post renaltransplant with a rifampicin sparingantituberculosis drug regimen. Pyrexia ofunknown origin was the most common manifestationobserved and a therapeutic trial withantituberculosis drugs is justified. De novodiabetes mellitus appears to be an added riskfactor and increases the susceptibility tomycobacterial infection.

Tuberculosis Renal transplantation Rifampicin sparing therapy Cyclosporine interaction 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Tushar J. Vachharajani
    • 1
    • 2
    Email author
  • Umesh G. Oza
    • 1
  • Ajit G. Phadke
    • 1
  • Ashok L. Kirpalani
    • 1
  1. 1.Department of TransplantationBombay Hospital Institute of Medical SciencesMumbaiIndia
  2. 2.Department of NephrologyLouisiana State University Health Sciences CenterShreveportUSA

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