Journal of Thermal Analysis and Calorimetry

, Volume 73, Issue 2, pp 597–605 | Cite as

The relevance of glass transition temperature for the process of tablet formation

  • K. M. Picker


The aim was to determine the relevance of the glass transition temperature (Tg) on the compressibility and compactibility of different excipients as celluloses, cellulose derivatives, lactoses, starch, maltodextrin and carrageenan. Their Tg was determined, they were tableted on an instrumented eccentric tableting machine and crushing force was analyzed. Using force, time and displacement tableting behavior was analyzed by 3D modeling. The parameters obtained, d (time plasticity), e (pressure plasticity) and w (fast elastic decompression), show different deformation mechanisms for the materials in relation to their Tg. Further, if the Tg can be reversibly exceeded during tableting, crushing force is high, otherwise crushing force is lower.

excipients DSC crushing force 3D model tableting glass transition temperature 


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  1. 1.
    R. P. Seelig and J. Wulff, Am. Inst. Mining Met. Engrs., Inst. Metals Div., Metals Technol., 13 (1946) 1.Google Scholar
  2. 2.
    J. T. Carstensen, Solid pharmaceutics, Mechanical properties and rate phenomena, Academic Press Inc., New York 1980, p. 187.Google Scholar
  3. 3.
    H. Leuenberger, Int. J. Pharm., 12 (1982) 41.CrossRefGoogle Scholar
  4. 4.
    H. Leuenberger and W. Jetzer, Powder Technol., 37 (1984) 209.CrossRefGoogle Scholar
  5. 5.
    A. Elamin, T. Sebhatu and C. Ahlneck, Int. J. Pharm., 119 (1995) 25.CrossRefGoogle Scholar
  6. 6.
    T. Sebhatu, C. Ahlneck and G. Alderborn, Int. J. Pharm., 146 (1997) 101.CrossRefGoogle Scholar
  7. 7.
    B. C. Hancock and G. Zografi, J. Pharm. Sci., 86 (1997) 1.CrossRefGoogle Scholar
  8. 8.
    K. van der Voort Maarschalk and G. K. Bolhuis, Pharm. Technol. Eur., 10 (1998) 30.Google Scholar
  9. 9.
    K. van der Voort Maarschalk and G. K. Bolhuis, Pharm. Technol. Eur., 10 (1998) 28.Google Scholar
  10. 10.
    K. van der Voort Maarschalk and G. K. Bolhuis, Pharm. Technol., 23 (1999) 34.Google Scholar
  11. 11.
    S. Yamamura, K. Terada and Y. Momose, J. Pharm. Pharmacol., 49 (1997) 1178.Google Scholar
  12. 12.
    V. Kumar and S. H. Kothari, Int. J. Pharm., 177 (1999) 173.CrossRefGoogle Scholar
  13. 13.
    P. W. S. Heng and N. Staniforth, J. Pharm. Pharmacol., 40 (1988) 360.Google Scholar
  14. 14.
    G. E. Amidon and M. E. Houghton, Pharm. Res., 12 (1995) 923.CrossRefGoogle Scholar
  15. 15.
    G. E. Reier and R. F. Shangraw J. Pharm. Sci., 55 (1966) 510.Google Scholar
  16. 16.
    K. M. Picker, Drug Dev. Ind. Pharm., 25 (1999) 329.CrossRefGoogle Scholar
  17. 17.
    E. J. Hanus and L. D. King, J. Pharm. Sci., 57 (1968) 677.Google Scholar
  18. 18.
    C. Führer and W. Parmentier, Acta Pharm. Technol., 23 (1977) 205.Google Scholar
  19. 19.
    A. S. Rankell and T. Higuchi. J. Pharm. Sci., 58 (1968) 574.Google Scholar
  20. 20.
    H. Bogs and E. Lenhardt, Pharm. Ind., 33 (1971) 850.Google Scholar
  21. 21.
    M. T. DeCrosta, J. B. Schwartz, R. J. Wigent and K. Marshall, Int. J. Pharm., 198 (2000) 113.CrossRefGoogle Scholar
  22. 22.
    M. T. DeCrosta, J. B. Schwartz, R. J. Wigent and K. Marshall, Int. J. Pharm., 213 (2001) 45.CrossRefGoogle Scholar
  23. 23.
    J. Ketolainen, J. Ilkka and P. Paronen, Int. J. Pharm., 92 (1993) 157.CrossRefGoogle Scholar
  24. 24.
    M. Beissenhirtz, Ph.D. Thesis, University of Bonn, 1974.Google Scholar
  25. 25.
    J. Schmidt, Ph.D. Thesis, University of Halle-Wittenberg, 1997.Google Scholar
  26. 26.
    H. McPhillips, D. Q. Craig, P. G. Royall, and V. L. Hill, Int. J. Pharm., 180 (1999) 83.CrossRefGoogle Scholar
  27. 27.
    V. L. Hill, D. Q. M. Craig and L. C. Feely, Int. J. Pharm., 161 (1998) 95.CrossRefGoogle Scholar
  28. 28.
    K. M. Picker and S. W. Hoag, J. Pharm. Sci., 91 (2002) 342.CrossRefGoogle Scholar
  29. 29.
    T. T. Kararli, J. B. Hurlbut and T. E. Needham, J. Pharm. Sci., 79 (1990) 845.Google Scholar
  30. 30.
    D. Q. M. Craig, P. G. Royall, L. V. Kett and L. M. Hopton, Int. J. Pharm., 179 (1999) 179.CrossRefGoogle Scholar
  31. 31.
    K. M. Picker and J. B. Mielck, Eur. J. Pharm. Biopharm., 42 (1996) 82.Google Scholar
  32. 32.
    K. M. Picker, Eur. J. Pharm. Biopharm., 49 (2000) 267.CrossRefGoogle Scholar
  33. 33.
    K. M. Picker and F. Bikane, Pharm. Dev. Technol., 6 (2001) 333.CrossRefGoogle Scholar
  34. 34.
    C. F. Lerk, Drug Dev. Ind. Pharm., 19 (1993) 2359.Google Scholar
  35. 35.
    H. Vromans, A. H. de Boer, G. K. Bolhuis, C. F. Lerk and K. D. Kussendrager, Acta Pharm. Suec., 22 (1985) 163.Google Scholar
  36. 36.
    H. Vromans, A. H. de Boer, G. K. Bolhuis, C. F. Lerk and K. D. Kussendrager and H. Bosch, Pharm. Weekbl. Sci., 7 (1985) 186.Google Scholar
  37. 37.
    H. Vromans, G. K. Bolhuis, C. F. Lerk, K. D. Kussendrager and H. Bosch, Acta Pharm. Suec., 23 (1986) 231.Google Scholar
  38. 38.
    T. Sebhatu and G. Alderborn, Eur. J. Pharm. Sci., 8 (1999) 235.CrossRefGoogle Scholar
  39. 39.
    K. M. Picker and J. B. Mielck, Pharm. Dev. Technol., 3 (1998) 1.CrossRefGoogle Scholar
  40. 40.
    K. M. Picker, PhD Thesis, University of Hamburg 1995.Google Scholar
  41. 41.
    M. Mitsuiki, Y. Yamamoto, A. Mizuno and M. Motoki, J. Agric. Food Chem., 46 (1998) 3528.CrossRefGoogle Scholar
  42. 42.
    K. J. Steffens, Proc. 1st World Meet. Pharm. Biopharm. Pharm. Technol., (1995) 143.Google Scholar
  43. 43.
    G. K. Bolhuis and Z. T. Chowhan, Materials for direct compaction. In: G. Alderborn and C. Nyström, Pharmaceutical powder compaction technology, Marcel Dekker Inc., New York 1996, p. 419.Google Scholar
  44. 44.
    K. M. Picker and F. Bikane, Int. J. Pharm., 175 (1998) 147.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers/Akadémiai Kiadó 2003

Authors and Affiliations

  • K. M. Picker
    • 1
  1. 1.Institute of Pharmaceutical Technology and BiopharmacyMartin-Luther-University, Halle-WittenbergHalle/SaaleGermany

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