Plasma Amino Acids Profiles in Children with Autism: Potential Risk of Nutritional Deficiencies
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The plasma amino acid profiles of 36 children with autism spectrum disorders were reviewed to determine the impact of diet on amino acid patterns. Ten of the children were on gluten and casein restricted diets administered by parents, while the other 26 consumed unrestricted diets. No amino acid profile specific to autism was identified. However, children with autism had more essential amino acid deficiencies consistent with poor protein nutrition than an age/gender matched control group. There was a trend for children with autism who were on restricted diets to have an increased prevalence of essential amino acid deficiencies and lower plasma levels of essential acids including the neurotransmitter precursors tyrosine and tryptophan than both controls and children with autism on unrestricted diets. These data indicate that larger, more focused studies of protein nutrition in children with autism are needed in order to determine the extent to which restricted diets might place the developing brains of children with autism at risk from protein malnutrition. The high rate of tryptophan and tyrosine deficiency in this group is also of concern given their role as neurotransmitter precursors.
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- Bryson, S. E., & Smith, I. M. (1998). Epidemiology of autism: Prevalence, associated characteristics and implications for research and service delivery. Mental Retard Dev Disability Research Review, 4, 97–103.Google Scholar
- Carvalho, P. H., Kenny, R. D., Carrington, P. H., & Hall, D. E. (2001). Severe nutritional deficiencies in toddlers resulting from health food mild alternatives. Pediatrics, 107(4);http://www. pediatrics.org/cgi/content/full/107/4/e46Google Scholar
- Filipek, P. A., Accardo, P. J., Baranek, G. T., Cook, E. H., Jr., Dawson, G., Gordon, B., Gravel, J. S., Johnson, C. P., Kallen, R. J., Levy, S. E., Minshew, N. J., Ozonoff, S., Prizant, B. M., Rapin, I., Rogers, S. J., Stone, W. L., Teplin, S., Tuchman, R. F., & Volkmar, F. R. (1999). The screening and diagnosis of autistic spectrum disorders. J Autism Dev Disord, 29(6), 439–484.CrossRefPubMedGoogle Scholar
- Jackson, M. J., & Garrod, P. J. (1978). Plasma zinc, copper and amino acid levels in the blood of autistic children. J Autism Childhood Schizophrenia, 8, 203–208.Google Scholar
- Johnson, R. J., Wiersema, V., & Kraft, I. A. (1974). Hair amino acids in autism. J Autism Childhood Schizophrenia, 4, 187–188.Google Scholar
- O'Banion, D., Armstrong, B., Cummings, R. A., & Stange, J. (1978). Disruptive behavior: A dietary approach. J Autism Childhood Schizophrenia, 8(3), 325–337.Google Scholar
- Reichelt, K. L., Ekrem, J., & Scott, H. (1990). Gluten, milk proteins and autism: dietary intervention effects on behavior and peptide secretion. J Applied Nutrition, 42, 1–11.Google Scholar
- Sandler, A. D., Brazdziunas, D., Cooley, W. C., González de Pijem, L., Hirsch, D., Kastner, T. A., Kummer, M. E., Quint, R. D., & Ruppert, E. S. (2001). Committee on Children Disabilities. Technical report: The pediatrician's role in the diagnosis and management of autistic spectrum disorders in children. Pediatrics, 107(5); http://www.pediatrics.org/cgi/content/full/107/5/e85Google Scholar
- Siegel, B. (1998). Early screening and diagnosis in autism spectrum disorders; the pervasive developmental disorder screening test (PDDST). Paper presented at the State of Science in Autism Screening and Diagnosis Working Conference, June 15–17, Bethesda, MD.Google Scholar
- Volkmar, F. R., Klin, A., Siegel, B., Szatmari, P., Lord, C., Campbell, M., Freeman, B. J., Cicchetti, D. V., Rutter, M., & Kline, W. (1994). Field trial for autistic disorder in DSM-IV. Am J Psych, 151, 1361–1367.Google Scholar