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Cancer Causes & Control

, Volume 14, Issue 5, pp 403–411 | Cite as

Non-steroidal anti-inflammatory drug use is associated with reduction in recurrence of advanced and non-advanced colorectal adenomas (United States)

  • Joseph A. TangreaEmail author
  • Paul S. Albert
  • Elaine Lanza
  • Karen Woodson
  • Don Corle
  • Marsha Hasson
  • Randall Burt
  • Bette Caan
  • Electra Paskett
  • Frank Iber
  • J. Walter Kikendall
  • Peter Lance
  • Moshe Shike
  • Joel Weissfeld
  • Arthur Schatzkin
Article

Abstract

Objective: To prospectively examine the association between non-steroidal anti-inflammatory drugs (NSAIDs) use (including dose and dosage schedule) and the recurrence of colorectal adenomas among individuals who were diagnosed with an adenoma at entry into a clinical trial. Methods: For this analysis, participants who completed the full follow-up (n = 1905) for the Polyp Prevention Trial (PPT) were evaluated. Information on current use and dose of NSAIDs and other drugs was obtained at baseline and at each subsequent study visit over the duration of the trial. The study endpoint was the recurrence of colorectal adenomas in the 3 years between the 1-year trial colonoscopy (T1) and the end of the trial colonoscopy (T4). Results: There was a significant reduction in overall adenoma recurrence among NSAIDs users (odds ratio [OR] = 0.77; 95% confidence interval [CI]: 0.63–0.95), with the greatest effect seen in advanced polyps (OR = 0.51; CI: 0.33–0.79). Among aspirin users, we observed a significant dose response for overall adenoma recurrence, with a 40% reduction in the OR association (OR = 0.56; 95% CI: 0.31–0.99) among those taking more than 325 mg per day. Conclusion: This prospective study provides further evidence that NSAIDs may play an important role in the chemoprevention of recurrent colorectal adenomas, even those with advanced features.

adenomas non-steroidal anti-inflammatory drugs prospective risk 

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Joseph A. Tangrea
    • 1
    Email author
  • Paul S. Albert
    • 2
  • Elaine Lanza
    • 3
  • Karen Woodson
    • 3
  • Don Corle
    • 4
  • Marsha Hasson
    • 5
  • Randall Burt
    • 6
  • Bette Caan
    • 7
  • Electra Paskett
    • 8
  • Frank Iber
    • 9
  • J. Walter Kikendall
    • 10
  • Peter Lance
    • 11
  • Moshe Shike
    • 12
  • Joel Weissfeld
    • 13
  • Arthur Schatzkin
    • 14
  1. 1.Center for Cancer Research, Cancer Prevention Studies BranchNational Cancer InstituteBethesdaUSA
  2. 2.Biometric Research Branch, Division of Cancer Treatment and DiagnosisNational Cancer InstituteBethesdaUSA
  3. 3.Cancer Prevention Studies Branch, Center for Cancer ResearchNational Cancer InstituteBethesdaUSA
  4. 4.Biometry Research Group, Division of Cancer PreventionNational Cancer InstituteBethesdaUSA
  5. 5.WestatRockvilleUSA
  6. 6.University of UtahSalt Lake CityUSA
  7. 7.Kaiser Foundation Research InstituteOaklandUSA
  8. 8.Wake Forest University School of MedicineWinston-SalemUSA
  9. 9.Edward Hines, Jr, HospitalVeterans Affairs Medical CenterHinesUSA
  10. 10.Walter Reed Army Medical CenterWashington, DCUSA
  11. 11.School of Medicine and Biomedical SciencesState University of New York at BuffaloBuffaloUSA
  12. 12.Memorial Sloan-Kettering Cancer CenterNew YorkUSA
  13. 13.University of PittsburghPittsburghUSA
  14. 14.Nutritional Epidemiology Branch, Division of Epidemiology and GeneticsNational Cancer InstituteBethesdaUSA

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