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Journal of Muscle Research & Cell Motility

, Volume 24, Issue 1, pp 55–63 | Cite as

The importance of alcohol-induced muscle disease

  • Victor R. Preedy
  • Kay Ohlendieck
  • Junko Adachi
  • Michael Koll
  • Alan Sneddon
  • Ross Hunter
  • Rajkumar Rajendram
  • David Mantle
  • Timothy J. Peters
Article

Abstract

Alcohol-induced muscle disease (AIMD) is a composite term to describe any muscle pathology (molecular, biochemical, structural or physiological) resulting from either acute or chronic alcohol ingestion or a combination thereof. The chronic form of AIMD is arguably the most prevalent skeletal muscle disorder in the Western Hemisphere affecting more than 2000 subjects per 100,000 population and is thus much more common than hereditary disorders such as Becker or Duchenne muscular dystrophy. Paradoxically, most texts on skeletal myopathies or scientific meetings covering muscle disease have generally ignored chronic alcoholic myopathy. The chronic form of AIMDs affects 40–60% of alcoholics and is more common than other alcohol-induced diseases, for example, cirrhosis (15–20% of chronic alcoholics), peripheral neuropathy (15–20%), intestinal disease (30–50%) or cardiomyopathy (15–35%). In this article, we summarise the pathological features of alcoholic muscle disease, particularly biochemical changes related to protein metabolism and some of the putative underlying mechanisms. However, the intervening steps between the exposure of muscle to ethanol and the initiation of the cascade of responses leading to muscle weakness and loss of muscle bulk remain essentially unknown. We argue that alcoholic myopathy represents: (a) a model system in which both the causal agent and the target organ is known; (b) a myopathy involving free-radical mediated pathology to the whole body which may also target skeletal muscle and (c) a reversible myopathy, unlike many hereditary muscle diseases. A clearer understanding of the mechanisms responsible for alcoholic myopathy is important since some of the underlying pathways may be common to other myopathies.

Keywords

Myopathy Muscle Protein Synthesis Duchenne Muscular Dystrophy Inclusion Body Myositis Myosin Heavy Chain Isoforms 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Victor R. Preedy
    • 1
  • Kay Ohlendieck
    • 2
  • Junko Adachi
    • 3
  • Michael Koll
    • 1
  • Alan Sneddon
    • 4
  • Ross Hunter
    • 1
  • Rajkumar Rajendram
    • 1
  • David Mantle
    • 5
  • Timothy J. Peters
    • 6
  1. 1.Department of Nutrition and DieteticsKing's College LondonLondonUK
  2. 2.Department of BiologyNational University of Ireland, Maynooth, CoKildareIreland
  3. 3.Department of Legal MedicineKobe University Graduate School of MedicineKobeJapan
  4. 4.Muscle Function Group, Rowett Research Institute, BucksburnAberdeenScotland
  5. 5.Department of Agricultural and Environmental ScienceNewcastle University, King George VI BuildingNewcastle upon TyneUK
  6. 6.Department of Clinical BiochemistryKing's College HospitalLondonUK

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