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Journal of Clinical Immunology

, Volume 23, Issue 4, pp 291–296 | Cite as

Association of −1087 IL10 and −308 TNFA Gene Polymorphisms with Serological Markers of Coeliac Disease

  • M. Hahn-Zoric
  • A. M. Hytönen
  • L. Å. Hanson
  • L. Å. Nilsson
  • L. Padyukov
Article

Abstract

Coeliac disease (CD) is known to have a strong genetic background. We analyzed the association between serological markers of CD and the −1087 IL10 and −308 TNFA gene polymorphisms in Swedish patients. A higher frequency of the TNF2 allele was present in the patients compared with the controls (p <0.0001). The frequency of the AA genotype of the IL10 gene in the patients was unexpectedly higher in comparison with the controls (p <0.05). The levels of IgA anti-endomysium and antitissue transglutaminase antibodies were associated with IL10 but not with TNFA genotype. The patients with the AA or GG −1087 IL10 genotypes had significantly lower levels of antibodies in comparison with those with the AG genotype (p <0.05 to p <0.0005). However, when divided according to potential level of IL-10 production, the group of potentially high IL-10 producers among the CD patients demonstrated significantly lower levels of antitissue transglutaminase antibodies compared to potentially low IL-10 producers (p = 0.01). Our results show a relationship between the levels of IgA antibodies involved in CD with the IL10 genotypes. This suggests a possible involvement of IL-10 in the development of the disease.

antibodies IL-10 TNF cytokine gene polymorphism 

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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • M. Hahn-Zoric
    • 1
  • A. M. Hytönen
    • 1
  • L. Å. Hanson
    • 1
  • L. Å. Nilsson
    • 2
  • L. Padyukov
    • 1
    • 3
  1. 1.Department of Clinical ImmunologyUniversity of GöteborgGöteborgSweden
  2. 2.Department of Medical Microbiology and ImmunologyUniversity of GöteborgGöteborgSweden
  3. 3.Immunoassay DepartmentMechnikov Research Institute for Vaccines & SeraMoscowRussia

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