Journal of Biological Physics

, Volume 29, Issue 2–3, pp 187–194

On-Chip THz Detection of Biomaterials: A Numerical Study

  • T. Baras
  • T. Kleine-Ostmann
  • M. Koch
Article

Abstract

The marker-free on-chip distinction betweenhybridised (double-stranded) DNA (HDNA) anddenatured (single-stranded) DNA (DDNA) hasrecently been demonstrated using ultrashortelectrical pulses. The electrical THzpulses propagate in integrated waveguidesincorporating resonant THz structures ontowhich the genetic material is deposited.For a possible future realisation of a highthroughput array, it is crucial to optimizethe experimental parameters and theresonant structure. In this paper weperform a first numerical study ofdifferent resonator geometries and examinethe influence of critical experimentalparameters on the transmissioncharacteristics of the resonant structures.Our simulations demonstrate that the ringresonator shows a comparable performance tothe parallel-coupled resonator previouslyused in a first demonstration by Nagel andcoworkers.

lab-on-chip marker-free DNA testing numerical simulations on-chip DNA analysis parallel-coupled filter ring resonator THz on-chip detection THz spectroscopy 

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • T. Baras
    • 1
  • T. Kleine-Ostmann
    • 1
  • M. Koch
    • 1
  1. 1.Institut für HochfrequenztechnikTechnische Universität Braunschweig SchleinitzstrasseBraunschweigGermany

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