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Breast Cancer Research and Treatment

, Volume 80, Issue 1, pp 127–131 | Cite as

Estrogen Receptor Alpha Gene Polymorphisms and Breast Cancer Risk

  • Aesun Shin
  • Daehee Kang
  • Hisahide Nishio
  • Myeong Jin Lee
  • Sue Kyung Park
  • Sook-Un Kim
  • Dong-Young Noh
  • Kuk-Jin Choe
  • Se-Hyun Ahn
  • Ari Hirvonen
  • Ju Han Kim
  • Keun-Young Yoo
Article

Abstract

We conducted a hospital-based case-control study to evaluate the association between the XbaI and PvuII restriction fragment length polymorphisms (RFLPs) in intron 1 of the estrogen receptor α (ERα) gene and breast cancer risk. The study population consisted of 205 histologically confirmed incident breast cancer cases and 205 age-matched controls with no present and previous history of cancer. The PvuII genotype distribution did not show any difference between cases and controls, but the adjusted odds ratio (OR) for the XbaI X allele containing genotypes was 0.4 (95% CI: 0.3–0.6) compared with the xx genotype. The decrease in the OR appeared to be more attributable to the postmenopausal women; the ORs were 0.3 (95% CI: 0.1–0.5) and 0.5 (95% CI: 0.3–0.9) for postmenopausal and premenopausal women, respectively. Our results therefore suggest that the ERα XbaI polymorphism modifies individual susceptibility to breast cancer in Korean women.

breast cancer estrogen receptors polymorphism (genetics) 

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Aesun Shin
    • 1
  • Daehee Kang
    • 1
  • Hisahide Nishio
    • 2
  • Myeong Jin Lee
    • 2
  • Sue Kyung Park
    • 3
  • Sook-Un Kim
    • 1
  • Dong-Young Noh
    • 4
  • Kuk-Jin Choe
    • 4
  • Se-Hyun Ahn
    • 5
  • Ari Hirvonen
    • 6
  • Ju Han Kim
    • 1
  • Keun-Young Yoo
    • 1
  1. 1.Department of Preventive MedicineSeoul National University College of MedicineSeoulSouth Korea
  2. 2.Division of Public HealthKobe University Graduate School of MedicineKobeJapan
  3. 3.Department of Preventive MedicineKonkuk University College of MedicineChungcheongbuk-doSouth Korea
  4. 4.Department of SurgerySeoul National University College of MedicineSeoulSouth Korea
  5. 5.Department of SurgeryUlsan University College of MedicineSeoulSouth Korea
  6. 6.Department of Industrial Hygiene and ToxicologyFinnish Institute of Occupational HealthHelsinkiFinland

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