Journal of Biological Physics

, Volume 29, Issue 2–3, pp 257–259 | Cite as

Terahertz Pulsed Imaging of Skin Cancer in the Time and Frequency Domain

  • R.M. Woodward
  • V.P. Wallace
  • D.D. Arnone
  • E.H. Linfield
  • M. Pepper
Article

Abstract

Terahertz Pulsed Imaging(TPI) is a new medical imaging modality forthe detection of epithelial cancers. Overthe last two years this technique has beenapplied to the study of in vitrobasal cell carcinoma (BCC). Usingtime-domain analysis the contrast betweendiseased and normal tissue has been shownto be statistically significant, andregions of increased terahertz (THz)absorption correlated well with thelocation of the tumour sites in histology.Understanding the source of this contrastthrough frequency-domain analysis mayfacilitate the diagnosis of skin cancer andrelated skin conditions using TPI. Wepresent the first frequency-domain analysisof basal cell carcinoma in vitro,with the raw power spectrum giving aninsight into the surface features of theskin. Further data manipulation is requiredto determine whether spectral informationcan be extrapolated at depth. These resultshighlight the complexity of working inreflection geometry.

Cancer epithelial frequency domain skin terahertz imaging time domain spectroscopy 

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • R.M. Woodward
    • 1
    • 2
  • V.P. Wallace
    • 1
  • D.D. Arnone
    • 1
  • E.H. Linfield
    • 2
  • M. Pepper
    • 2
  1. 1.TeraView Limited, 302/304 Science ParkCambridgeUK
  2. 2.Cavendish LaboratoryUniversity of CambridgeCambridgeUK

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