Neurochemical Research

, Volume 28, Issue 8, pp 1181–1186 | Cite as

Effects of Undernutrition on Glutamatergic Parameters in Rat Brain

  • Liane N. Rotta
  • André P. Schmidt
  • Tadeu Mello e Souza
  • Cristina W. Nogueira
  • Karine B. Souza
  • Ivan A. Izquierdo
  • Marcos L. S. Perry
  • Diogo O. Souza


Early restriction of nutrients during the perinatal period has marked repercussions on CNS ontogeny, Leading to impaired functions. This study investigated the effects of pre- and postnatal (up to 75 days) undernutrition (diet: 8% protein; normonourished group: 25% protein) on some glutamatergic and behavioral parameters of rats. Undernutrition reduced: (i) seizures caused by ICV quinolinic acid (QA) administration; (ii) Na-independent [3H]glutamate binding in cell plasma membranes of cerebral cortex, and (ii) basal [3H]glutamate release from synaptosomal preparation. Behavioral parameters related to locomotion, anxiety, or memory were not affected. These results indicate that our model of undernutrition decreased the sensitivity to QA as convulsing agent and point to some putative glutamatergic parameters involved in this effect.

Undernutrition glutamatergic system quinolinic acid seizures behavioral parameters 


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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Liane N. Rotta
    • 1
    • 2
  • André P. Schmidt
    • 1
  • Tadeu Mello e Souza
    • 1
  • Cristina W. Nogueira
    • 3
  • Karine B. Souza
    • 1
  • Ivan A. Izquierdo
    • 1
  • Marcos L. S. Perry
    • 1
  • Diogo O. Souza
    • 1
  1. 1.Departamento de Bioquímica, Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto Alegre, RSBrazil
  2. 2.Faculdade de FarmáciaUniversidade Luterana do BrasilCanoas, RSBrazil
  3. 3.Departamento de Química, Centro de Ciências Naturais e ExatasUniversidade Federal de Santa MariaSanta Maria, RSBrazil

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