, Volume 118, Issue 2–3, pp 279–294

Population-Genetic Models of the Fates of Duplicate Genes

  • Bruce Walsh

DOI: 10.1023/A:1024194802441

Cite this article as:
Walsh, B. Genetica (2003) 118: 279. doi:10.1023/A:1024194802441


The ultimate fate of a duplicated gene is that it either silenced through inactivating mutations or both copies are maintained by selection. This later fate can occur via neofunctionalization wherein one copy acquires a new function or by subfunctionalization wherein the original function of the gene is partitioned across both copies. The relative probabilities of these three different fates involve often very subtle iterations between of population size, mutation rate, and selection. All three of these fates are critical to the expansion and diversification of gene families.

evolution of new gene function gene families gene silencing neofunctionalization pseudogenes subfunctionalization 

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Bruce Walsh
    • 1
  1. 1.Departments of Ecology and Evolutionary Biology, Molecular and Cellular Biology, and Plant SciencesUniversity of ArizonaTucsonUSA

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