Synthesis and biocompatibility of porous nano-hydroxyapatite/collagen/alginate composite

  • S. M. Zhang
  • F. Z. Cui
  • S. S. Liao
  • Y. Zhu
  • L. Han
Article

Abstract

Porous nano-hydroxyapatite/collagen/alginate (nHAC/Alginate) composite containing nHAC and Ca-crosslinked alginate is synthesized biomimetically. This composite shows a significant improvement in mechanical properties over nHAC material. Mechanical test results show that the compressive modulus and yield strength of this composite are in direct proportion to the percentage of Ca-crosslinked alginate in the composite. Primary biocompatibility experiments in vitro including fibroblasts and osteoblasts co-culture with nHAC/alginate composite indicated the high biocompatibility of this composite. Therefore the composite can be a promising candidate of scaffold material for bone tissue engineering.

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • S. M. Zhang
    • 1
  • F. Z. Cui
    • 1
  • S. S. Liao
    • 1
  • Y. Zhu
    • 1
  • L. Han
    • 1
  1. 1.Department of Materials Science &Engineering, Tsinghua UniversityBeijingRepublic of China

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