Breast Cancer Research and Treatment

, Volume 79, Issue 3, pp 391–397

Use of the Peroxisome Proliferator-Activated Receptor (PPAR) γ Ligand Troglitazone as Treatment for Refractory Breast Cancer: A Phase II Study

  • Harold J. Burstein
  • George D. Demetri
  • Elisabetta Mueller
  • Pasha Sarraf
  • Bruce M. Spiegelman
  • Eric P. Winer
Article

Abstract

Purpose. To evaluate the therapeutic effects of the peroxisome proliferator-activated receptor (PPAR) γ activating ligand, troglitazone, in patients with refractory metastatic breast cancer.

Experimental design. Patients with advanced breast cancer refractory to at least one chemotherapy regimen (ER negative tumors) or two hormonal regimens (ER positive tumors) were treated with troglitazone at 800 mg PO QD until disease progression, to determine the percentage of patients free of progression at 6 months. Tumor response, toxicity, and changes in serum tumor markers (CEA, CA27.29) that might reflect alteration in tumor differentiation, were also examined.

Results. Twenty-two patients were enrolled before suspension of protocol accrual and treatment when troglitazone was withdrawn from commercial availability following FDA warnings on hepatic toxicity. No objective responses (CR or PR) were observed; only three patients had SD at 8 weeks. Patients came off study for PD (16), DLT (1), FDA withdrawal (2), or other (3) reasons. No patients took troglitazone for more than 20 weeks; all had experienced disease progression or began other systemic therapy within 6 months. All patients with elevated serum tumor markers (CEA and CA27.29) at baseline had rising tumor markers within 8 weeks.

Conclusions. While clinical trials among different patient populations might uncover subtle effects on tumor differentiation, PPARγ activation by troglitazone has little apparent clinical value among patients with treatment-refractory metastatic breast cancer.

breast cancer clinical trials peroxisome proliferator-activated receptor (PPAR) thiazolidinediones troglitazone 

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Harold J. Burstein
    • 1
    • 2
  • George D. Demetri
    • 1
    • 2
  • Elisabetta Mueller
    • 3
  • Pasha Sarraf
    • 3
  • Bruce M. Spiegelman
    • 3
  • Eric P. Winer
    • 1
    • 2
  1. 1.Department of Medical OncologyDana-Farber Cancer InstituteBostonUSA
  2. 2.Department of MedicineBrigham & Women's Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Department of Cancer BiologyDana-Farber Cancer InstituteBostonUSA

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