Bulletin of Experimental Biology and Medicine

, Volume 135, Issue 2, pp 114–116 | Cite as

Effect of Antibodies to Morphine on Synaptic Plasticity of the Hippocampus

  • N. A. Beregovoi
  • T. M. Pankova
  • N. S. Sorokina
  • M. V. Starostina


Incubation of hippocampal slices with antibodies to morphine did not change the total excitatory postsynaptic potential of mossy fibers, but markedly facilitated long-term posttetanic potentiation. Culturing of the organotypic hippocampal culture in the presence of 10 μM morphine increased the total excitatory postsynaptic potential of mossy fibers and reduced the probability of long-term posttetanic potentiation.

morphine antibodies hippocampus long-term posttetanic potentiation 


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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • N. A. Beregovoi
    • 1
  • T. M. Pankova
    • 1
  • N. S. Sorokina
    • 1
  • M. V. Starostina
    • 1
  1. 1.Siberian Division of the Russian Academy of Medical SciencesInstitute of Molecular Biology and BiophysicsNovosibirsk

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