Molecular and Cellular Biochemistry

, Volume 246, Issue 1–2, pp 45–50

The effect of early treatment by cerivastatin on the serum level of C-reactive protein, interleukin-6, and interleukin-8 in patients with unstable angina and non-Q-wave myocadial infarction

  • Petr Ostadal
  • David Alan
  • Petr Hajek
  • David Horak
  • Jiri Vejvoda
  • Jiri Trefanec
  • Martin Mates
  • Jan Vojacek
Article

DOI: 10.1023/A:1023499727477

Cite this article as:
Ostadal, P., Alan, D., Hajek, P. et al. Mol Cell Biochem (2003) 246: 45. doi:10.1023/A:1023499727477

Abstract

The aim of our study was to evaluate whether a single dose of cerivastatin at the time of admission of patients with unstable angina pectoris (UAP) or non-Q-wave myocardial infarction (NQMI) can influence the serum level of C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) 24 h later. Forty-four patients with rest chest pain and subendocardial ischemia on ECG were randomized to receive cerivastatin 0.3 mg at the time of admission (group C+) to standard therapy or to remain just on standard therapy (group C−). Blood samples for determination of troponin I (TI), CRP, IL-6 and IL-8 were collected at admission (entry level) and 24 h later (final level). Patients with non-physiological baseline levels of TI, as well as patients with progression to Q wave MI were excluded. All baseline, clinical and demographic data and final values of TI were comparable in the two groups. In patients treated with cerivastatin (group C+, n = 13) we observed decrease in the CRP level (−6.73 ± 3.93 mg/L); on the other hand, in group C− (n = 17) the CRP level increased (+7.92 ± 2.77 mg/L, p = 0.004). Similar differences were observed also in IL-6: in group C+ the level was significantly reduced as compared with the increase in group C− (−0.76 ± 0.52 vs. 4.58 ± 1.49 ng/L, p = 0.005). The level of IL-8 was not affected. Our results suggest that early treatment with cerivastatin can decrease the serum level of CRP and IL-6 in patients with UAP/NQMI; this might positively influence their prognosis. Nevertheless, further studies are needed to support this hypothesis.

cerivastatin inflammation C-reactive protein interleukin unstable angina myocardial infarction 

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Petr Ostadal
    • 1
    • 2
  • David Alan
    • 1
    • 2
  • Petr Hajek
    • 1
    • 2
  • David Horak
    • 1
    • 2
  • Jiri Vejvoda
    • 1
    • 2
  • Jiri Trefanec
    • 1
    • 2
  • Martin Mates
    • 1
    • 2
  • Jan Vojacek
    • 1
    • 2
  1. 1.Department of Internal MedicineUniversity Hospital MotolCzech Republic
  2. 2.2nd Medical FacultyCharles UniversityPragueCzech Republic

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