Journal of Muscle Research & Cell Motility

, Volume 23, Issue 5–6, pp 367–375 | Cite as

Section: DNA, Chromatin and Chromosomes; Mechanics and imaging of single DNA molecules

  • M. Hegner
  • W. Grange


We review recent experiments that have revealed mechanical properties of single DNA molecules using advanced manipulation and force sensing techniques (scanning force microscopy (SFM), optical or magnetic tweezers, microneedles). From such measurements, intrinsic relevant parameters (persistence length, stretch modulus) as well as their dependence on external parameters (non-physiological conditions, coating with binding agents or proteins) are obtained on a single-molecule level. In addition, imaging of DNA molecules using SFM is presented.


Optical Tweezer Persistence Length Contour Length Magnetic Tweezer dsDNA Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • M. Hegner
    • 1
  • W. Grange
    • 1
  1. 1.Institute of Physics, NCCR Nanoscale ScienceUniversity of BaselBaselSwitzerland

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