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European Journal of Epidemiology

, Volume 18, Issue 3, pp 203–209 | Cite as

Genotype–phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene

  • I. Kato
  • J. Eastham
  • B. Li
  • M. Smith
  • H. Yu
Article

Abstract

Polymorphic microsatellite dinucleotide (cytosine–adenine, CA) repeats of the insulin-like growth factor-I (IGF-I) gene may have implications in the development of certain types of cancer and osteoporosis. We studied correlations between IGF-I genotypes determined by direct sequencing and plasma IGF-I levels among 113 healthy individuals (60 men and 53 women), who were originally enrolled as controls for hospital-based case–control studies of breast and prostate cancer. On the contrary to an earlier observation, there were no differences in plasma IGF-I levels between those with and without the allele of 19 repeats. With adjustment for other confounders, there were no trends in plasma IGF-I levels with increasing or decreasing the number of CA repeats among all study subjects combined, all Whites or all Blacks, suggesting no overall functional significance of this polymorphism. Opposite trends observed in gender and racial subgroups, i.e., an inverse association between plasma IGF-I levels and the CA repeat length in white women and a positive association in black men, are likely to be chance findings.

Genetic polymorphism Insulin-like growth factor-I Microsatellite repeats 

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • I. Kato
    • 1
    • 2
  • J. Eastham
    • 3
    • 4
  • B. Li
    • 5
  • M. Smith
    • 2
  • H. Yu
    • 6
    • 2
  1. 1.Karmanos Cancer Institute/Department of PathologyWayne State UniversityDetroitUSA
  2. 2.Section of Cancer Prevention and Control, Feist–Weiller Cancer CenterLouisiana State University Health Sciences CenterUSA
  3. 3.Sections of Urologic Oncology, Feist–Weiller Cancer CenterLouisiana State University Health Sciences CenterShreveportUSA
  4. 4.Department of UrologyMemorial Sloan Kettering Cancer CenterNew YorkUSA
  5. 5.Section of Surgical Oncology, Feist–Weiller Cancer CenterLouisiana State University Health Sciences CenterShreveportUSA
  6. 6.Department of Epidemiology and Public HealthYale University School of MedicineNew HavenUSA

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