Journal of Statistical Physics

, Volume 90, Issue 5–6, pp 1481–1487

Nonequilibrium Measurements of Free Energy Differences for Microscopically Reversible Markovian Systems

  • Gavin E. Crooks

DOI: 10.1023/A:1023208217925

Cite this article as:
Crooks, G.E. Journal of Statistical Physics (1998) 90: 1481. doi:10.1023/A:1023208217925


An equality has recently been shown relating the free energy difference between two equilibrium ensembles of a system and an ensemble average of the work required to switch between these two configurations. In the present paper it is shown that this result can be derived under the assumption that the system's dynamics is Markovian and microscopically reversible.

Nonequilibrium statistical mechanics free energy work thermodynamic integration thermodynamic perturbation 

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Gavin E. Crooks
    • 1
  1. 1.Department of ChemistryUniversity of CaliforniaBerkeleyCalifornia

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