Journal of Autism and Developmental Disorders

, Volume 29, Issue 3, pp 195–201

Exclusion of Linkage to the HLA Region in Ninety Multiplex Sibships with Autism

  • Tamara Rogers
  • Luba Kalaydjieva
  • Joachim Hallmayer
  • P. Brent Petersen
  • Peter Nicholas
  • Carmen Pingree
  • William M. McMahon
  • Donna Spiker
  • Linda Lotspeich
  • Helena Kraemer
  • Patty McCague
  • Sue Dimiceli
  • Nassim Nouri
  • Tawna Peachy
  • Joan Yang
  • David Hinds
  • Neil Risch
  • Richard M. Myers
Article

Abstract

Several studies have suggested a role for the histocompatibility complex of loci (HLA) in the genetic susceptibility to autism. We have tested this hypothesis by linkage analysis using genetic marker loci in the HLA region on chromosome 6p in multiplex families with autism. We have examined sharing of alleles identical by descent in 97 affected sib pairs from 90 families. Results demonstrate no deviation from the null expectation of 50% sharing of alleles in this region; in fact, for most marker loci, the observed sharing was less than 50%. Thus, it is unlikely that loci in this region contribute to the genetic etiology of autism to any significant extent in our families.

Histocompatibility HLA region autism-affected sib pairs 

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Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Tamara Rogers
    • 1
  • Luba Kalaydjieva
    • 1
  • Joachim Hallmayer
    • 2
  • P. Brent Petersen
    • 3
  • Peter Nicholas
    • 3
  • Carmen Pingree
    • 3
  • William M. McMahon
    • 3
  • Donna Spiker
    • 4
  • Linda Lotspeich
    • 4
  • Helena Kraemer
    • 4
  • Patty McCague
    • 4
  • Sue Dimiceli
    • 4
  • Nassim Nouri
    • 5
  • Tawna Peachy
    • 5
  • Joan Yang
    • 5
  • David Hinds
    • 5
  • Neil Risch
    • 5
  • Richard M. Myers
    • 5
  1. 1.Centre for Human GeneticsEdith Cowan UniversityPerthAustralia
  2. 2.Centre for Clinical Research in NeuropsychiatryGraylands Hospital/University of Western AustraliaPerthAustralia
  3. 3.Department of PsychiatryUniversity of UtahSalt Lake City
  4. 4.Department of Psychiatry and Behavioral SciencesStanford University School of MedicineStanford
  5. 5.Department of GeneticsStanford University School of MedicineStanford

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