Digestive Diseases and Sciences

, Volume 48, Issue 5, pp 968–975

Nodular Gastritis in Adults Is Caused by Helicobacter pylori Infection

  • Masaki Miyamoto
  • Ken Haruma
  • Masaharu Yoshihara
  • Toru Hiyama
  • Masaaki Sumioka
  • Takashi Nishisaka
  • Shinji Tanaka
  • Kazuaki Chayama
Article

DOI: 10.1023/A:1023016000096

Cite this article as:
Miyamoto, M., Haruma, K., Yoshihara, M. et al. Dig Dis Sci (2003) 48: 968. doi:10.1023/A:1023016000096

Abstract

A close relationship exists between nodular gastritis and Helicobacter pylori infection in children. The pathogenesis and optimal management of nodular gastritis in adults, however, are unclear. This study describes the clinicopathologic features of nodular gastritis in adults and correlates treatment with outcome. Of 97,262 adult patients who underwent endoscopy, 187 (0.19%) were diagnosed with nodular gastritis, 151 (81%) of whom had dyspepsia. Nodular gastritis predominantly affects young women (49 men and 138 women, mean age, 32.6 years). All 134 patients tested for Helicobacter pylori infection were infected, and 65/66 (98%) had inflammation of both the antrum and the corpus. Twenty-five (13%) had associated lesions (peptic ulcers or cancer). Dyspepsia improved after eradication of Helicobacter pylori infection, but did not improve spontaneously. Nodular gastritis in adults is caused by Helicobacter pylori infection and shows a predilection for females and young adults. Helicobacter pylori eradication decreases symptoms and reduces the risk of peptic ulcers and possibly gastric cancer.

nodular gastritis Helicobacter pylori eradication therapy epidemiology 

Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Masaki Miyamoto
    • 1
  • Ken Haruma
    • 2
  • Masaharu Yoshihara
    • 3
  • Toru Hiyama
    • 4
  • Masaaki Sumioka
    • 5
  • Takashi Nishisaka
    • 6
  • Shinji Tanaka
    • 5
  • Kazuaki Chayama
    • 1
  1. 1.First Department of Internal MedicineHiroshima University School of Medicine, 1-2-3 Kasumi, Minami-kuHiroshimaJapan
  2. 2.Division of Gastroenterology, Department of Internal MedicineKawasaki Medical School, 577 MatsushimaKurashikiJapan
  3. 3.Health Service CenterHiroshima University 1-7-1 KagamiyamaHigashihiroshimaJapan
  4. 4.Department of Internal MedicineHiroshima University School of Medicine, 1-2-3 Kasumi, Minami-kuHiroshimaJapan
  5. 5.Department of EndoscopyHiroshima Prefectural Hiroshima Hospital, 1-5-54 Ujinakanda, Minami-kuHiroshimaJapan
  6. 6.Department of PathologyHiroshima Prefectural Hiroshima Hospital, 1-5-54 Ujinakanda, Minami-ku, HiroshimaJapan

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