Digestive Diseases and Sciences

, Volume 48, Issue 4, pp 824–829 | Cite as

Effects of Quercetin on Liver Damage in Rats with Carbon Tetrachloride-Induced Cirrhosis

  • Amalia Pavanato
  • María J. Tuñón
  • Sonia Sánchez-Campos
  • Claudio A. Marroni
  • Susana Llesuy
  • Javier González-Gallego
  • Norma Marroni


Flavonoids are reported to exhibit a wide variety of biological effects, including antioxidant and free radical-scavenging activities. Evidence of oxidative reactions is often associated with various chronic disease processes characterized by accumulation of connective tissue. This study was aimed to investigate the protective effects of chronic administration of the flavonoid quercetin (150 μmol/kg body wt/day intraperitoneally) in rats with carbon tetrachloride-induced fibrosis. In animals rendered cirrhotic by administration of carbon tetrachloride for 16 weeks, cell necrosis, fibrosis, and inflammatory infiltration were found. Histological abnormalities were accompanied by a higher hepatic content of collagen and thiobarbituric acid-reactive substances. Expression of inducible nitric oxide synthase (iNOS) was significantly increased in the liver. Treatment with quercetin during 3 weeks improved liver histology and reduced collagen content, iNOS expression, and lipid peroxidation. Those effects were associated with an increased total peroxyl radical-trapping antioxidant capacity of liver. We conclude that quercetin is effective in this model of liver damage.

cirrhosis carbon tetrachloride quercetin lipid peroxidation nitric oxide 


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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Amalia Pavanato
    • 1
  • María J. Tuñón
    • 2
  • Sonia Sánchez-Campos
    • 2
  • Claudio A. Marroni
    • 3
  • Susana Llesuy
    • 4
  • Javier González-Gallego
    • 2
  • Norma Marroni
    • 1
  1. 1.ULBRA-Cachoeira do Sul e CanoasBrasil
  2. 2.Department of PhysiologyUniversity of León, LéonSpain
  3. 3.Faculdad Federal de Ciências Médicas de Porto AlegreBrasil
  4. 4.Pharmacy and Biochemistry SchoolUniversity of Buenos AiresArgentina

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