Current state of the art of biphasic calcium phosphate bioceramics

  • Guy Daculsi
  • Olivier Laboux
  • Olivier Malard
  • Pierre Weiss

Abstract

We have developed 15 years ago, with the collaboration of Lynch, Nery, and LeGeros in the USA, a bioactive concept based on biphasic calcium phosphate (BCP) ceramics. The concept is determined by an optimum balance of the more stable phase of HA and more soluble TCP. The material is soluble and gradually dissolves in the body, seeding new bone formation as it releases calcium and phosphate ions into the biological medium. The bioactive concept based on the dissolution/transformation processes of HA and TCP has been applied to both Bulk, Coating and Injectable Biomaterials. The events at the calcium phosphate (CaP) biomaterial/bone interface represent a dynamic process, including physico-chemical processes, crystal/proteins interactions, cells and tissue colonization, bone remodeling, finally contributing to the unique strength of such interfaces. An important literature and numerous techniques have been used for the evaluation of the fundamental physico chemical and biological performance of BCP concept. This type of artificial bone used from a long time in preclinical and in clinical trial, revealed the efficiency for bone filling, performance for bone reconstruction and efficacy for bone ingrowth at the expense of the micro macroporous BCP bioceramics.

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References

  1. 1.
    K. De Groot, in “Bioceramics of Calcium Phosphate” (CRC Press, Boca Raton, 1983) p. 100.Google Scholar
  2. 2.
    L. L. Hench, J. Am. Ceram. Soc. 74 (1994) 1487.Google Scholar
  3. 3.
    M. Jarcho, Clin. Orthop. 157 (1981) 259.Google Scholar
  4. 4.
    G. Daculsi, J. M. Bouler and R. Z. Legeros, Int. Rev. Cytol., 172 (1996) 129.Google Scholar
  5. 5.
    M. Heughebaert, R. Z. Legeros, M. Gineste and A. Guilhem, J. Biomed. Mater. Res. 22 (1988) 257.Google Scholar
  6. 6.
    G. Daculsi, R. Z. Legeros, E. Nery, K. Lynch and B. Kerebel, J. Biomed. Mater. Res. 23 (1989) 883.Google Scholar
  7. 7.
    G. Daculsi, R. Z. Legeros, M. Heugheaert and Barbieux., Calcif. Tissue Int. 46 (1990) 20.Google Scholar
  8. 8.
    R. Z. Legeros, in “Calcium Phosphates in Oral Biology and Medicine”, Monographs in Oral Sciences, Vol. 15, edited by H. Myers (S. Karger, Basel, 1991).Google Scholar
  9. 9.
    R. Z. Legeros and G. Daculsi, in “Handbook of Bioactive Ceramics, Calcium Phosphate and Hydroxylapatite Ceramics”, edited by T. Yamamuro, L. L. Hench and J. W. Wilson-Hench (CRC Press, Amsterdam, 1990) p. 2.Google Scholar
  10. 10.
    G. Daculsi, R. Z. Legeros and D. Mitre, Calcif. Tissue Int. 45 (1989) 95.Google Scholar
  11. 11.
    F. H. Albee, Ann. Surg. 71 (1920) 32.Google Scholar
  12. 12.
    S. N. Bhaskar, J. M. Brady, L. Getter, M. F. Grower and T. Driskell, J. Oral Surg. 32 (1971) 336.Google Scholar
  13. 13.
    E. B. Nery, K. L. Lynch, W. M. Hirthe and K. H. Mueller, J. Periodontol. 46 (1975) 328.Google Scholar
  14. 14.
    G. Daculsi, R. Z. Legeros and C. Deudon, Scan. Micr. 4 (1990) 309.Google Scholar
  15. 15.
    L. L. Hench, R. J. Splinter, W. C. Allen and T. K. Greelee, J. Biomed. Mater. Res. 2 (1971) 117.Google Scholar
  16. 16.
    H. Yuan, K. Kurashina, D. Joost De Bruijn, Y. Li, K. De Groot and X. Zhang, Biomaterials 20 (1999) 1799.Google Scholar
  17. 17.
    O. Malard, O. Gautier, P. Bordure and G. Daculsi, in “Proceedings of EMBEC 02 Vienna” (December, 2002) (in press).Google Scholar
  18. 18.
    R. Z. Legeros, Adv. Dent. Res. 2 (1988) 164.Google Scholar
  19. 19.
    R. Z. Legeros, J. P. Legeros, G. Daculsi and R. Kijkowska, in “Encyclopedic Handbook of Biomaterials and Bioengineering”, Part A: Materials, Vol. 2, edited by D. L. Wise et al. (M. Dekker Inc., New York, 1995) p. 1429.Google Scholar
  20. 20.
    G. Daculsi, Biomaterials, 19 (1998) 1473.Google Scholar
  21. 21.
    W. Bonfield, in “Bioceramics: Materials Characteristics Versus In Vivo Behavior”, edited by P. Ducheyne and J. E. Lemons Ann. NY. Acad. Sci. 523 (1988) 173.Google Scholar
  22. 22.
    P. Ducheyne, M. Marcolongco and E. Schepers, in “An Introduction to Bioceramics”, edited by L. L. Hench and J. Wilson (World Scientific Publishers, London, 1993) p. 281.Google Scholar
  23. 23.
    B. R. Constanz, I. C. Ison, M. T. Fulmer, R. D. Poser, S. T. Smith, M. Vanwagoner, J. Ross and S. A. Goldstein, Science 267 (1995) 1796.Google Scholar
  24. 24.
    G. Daculsi, P. Weiss, J. M. Bouler, O. Gauthier and E. Aguado, Bone 25 (1999) 59.Google Scholar
  25. 25.
    F. Millot, G. Grimandi, P. Weiss and G. Daculsi, Cells Mater. 9 (1999) 21.Google Scholar
  26. 26.
    G. Daculsi, P. Weiss, J. Delecrin, G. Grimandi, N. Passuti and F. Guerin, Composition pour biomatériau -procédé de préparation, Patent No 94-01-414 1994235 (1994).Google Scholar

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Guy Daculsi
    • 1
  • Olivier Laboux
    • 1
  • Olivier Malard
    • 1
  • Pierre Weiss
    • 1
  1. 1.Faculté de Chirurgie DentaireCentre de recherche sur les matériaux d'intérêt biologique INSERM E 99-03Nantes Cedex 01France

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