Journal of Medical Systems

, Volume 22, Issue 2, pp 89–93 | Cite as

Influence of Smoking on Serum Carcinoembryonic Antigen Levels in Subjects Who Underwent Multiphasic Health Testing and Services

  • I. Fukuda
  • M. Yamakado
  • H. Kiyose


We quantified the effect of smoking on serum carcinoembryonic antigen (CEA) levels in 1341 subjects who underwent the multiphasic health testing and services in our center. Four hundred and sixty seven of them were smokers and the rest were nonsmokers. In male subjects, serum CEA levels were significantly higher in smokers (3.11 ±1.8 ng/ml) than in nonsmokers (2.14 ± 1.8 ng/ml) (mean ± SD;p < 0.01). For females, however, the levels had no significant differences between smokers (2.11 ± 0.91 ng/ml) and nonsmokers (1.87 ± 1.3 ng/ml). The CEA-positive subjects were 44, of whom 32 were male custom heavy smokers, and only 2 of them had gastrointestinal cancer. We concluded that the serum CEA level was influenced by smoking especially in males and its clinical significance for detection of carcinoma was doubtful.

carcinoembryonic antigen smoking gastrointestinal cancer multiphasic health testing and services 


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  1. 1.
    Gold, P, Freedmann SO. Demonstration of tumorspecific antigens in human colonic carcinoma by immunological tolerance and absorption techniques. J. Exp. Med. 121:439–462, 1965.Google Scholar
  2. 2.
    Holyoke, E.D., Reynoso, G., and Chu. T.M. Carcinoembryonic antigen (CEA) in patients with carcinoma of the digestive tract. Ann. Surg. 176:559–564, 1972.Google Scholar
  3. 3.
    Holyoke, E.D., Chu, T.M., Murphy, G.P., CEA as a monitor of gastrointestinal malignancy. Cancer 35:830–836, 1975.Google Scholar
  4. 4.
    Fujishima, T., Honda, Y., Shijubo, N., and Takahashi, H., Abe, S. Increased carcinoembryonic antigen concentrations in sera and bronchoalveolar lavage fluids of patients with pulmonary alveolar proteinosis. Respiration 62:317–21, 1995.Google Scholar
  5. 5.
    Rule A.H., Straus, E., Vandevoorde, J., and Janowitz, H.D., Tumor-associated (CEA-reacting) antigen in patients with inflammatory bowel disease. N. Engl. J. Med. 287:24–26, 1972.Google Scholar
  6. 6.
    Stevens, D.P., et al.: Increased carcinoembryonic antigen in heavy cigarette smokers. Lancet 2:1238–1239, 1973.Google Scholar
  7. 7.
    Alexander, J.C., Silverman, N.A., and Chretien, P.B., Effect of age and cigarette smoking on carcinoembryonic antigen levels. JAMA 235:1975–1979, 1976.Google Scholar
  8. 8.
    Khoo, S.K., and Mackay, I.R.. Carcinoembryonic antigen in serum in diseases of the liver and pancreas. J. Clin. Pathol. 26:470–475, 1973.Google Scholar
  9. 9.
    Shahangian, S., Fritsche, H.A., and Hughes, J.I., Carcinoembryonic antigen in serum of patients with colorectal polyps: Correlation with histology and smoking status. Clin. Chem. 37:651–655, 1991.Google Scholar
  10. 10.
    Herrana, M.A., Chu, T.M., and Holyoke, E.D., Carcinoembryonic antigen (CEA) as a prognostic and monitoring test in clinically complete resection of colorectal carcinoma. Ann. Surg. 183:5–9, 1976.Google Scholar
  11. 11.
    Umehara, Y., Kimura, T., Yoshida, M., Oba, N., and Harada, Y., Comparison of doubling times of serum carcinoembryonic antigen produced by various metastatic lesions in recurrent gastric and colorectal carcinomas. Cancer 71:4055–4059, 1993.Google Scholar

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • I. Fukuda
  • M. Yamakado
  • H. Kiyose

There are no affiliations available

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