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Clinical & Experimental Metastasis

, Volume 20, Issue 1, pp 69–76 | Cite as

Collapsin response mediator protein-1: A novel invasion-suppressor gene

  • Jin-Yuan Shih
  • Yuan-Chii G. Lee
  • Shuenn-Chen Yang
  • Tse-Ming Hong
  • Chi-Ying F. Huang
  • Pan-Chyr Yang
Article

Abstract

Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-1 inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-1 mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells.

CRMP invasion metastasis microarray semaphorin 

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Jin-Yuan Shih
    • 1
  • Yuan-Chii G. Lee
    • 2
  • Shuenn-Chen Yang
    • 3
  • Tse-Ming Hong
    • 3
  • Chi-Ying F. Huang
    • 2
  • Pan-Chyr Yang
    • 1
    • 2
    • 3
  1. 1.Department of Internal MedicineNational Taiwan University HospitalTaipeiTaiwan
  2. 2.National Health Research InstitutesTaipeiTaiwan
  3. 3.Academia SinicaInstitute of Biomedical SciencesTaipeiTaiwan

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