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Neurochemical Research

, Volume 28, Issue 2, pp 195–214 | Cite as

Metabolism and Functions of Phosphatidylserine in Mammalian Brain

  • Rita Mozzi
  • Sandra Buratta
  • Gianfrancesco GoracciEmail author
Article

Abstract

Phosphatidylserine (PtdSer) is involved in cell signaling and apoptosis. The mechanisms regulating its synthesis and degradation are still not defined. Thus, its role in these processes cannot be clearly established at molecular level. In higher eukaryotes, PtdSer is synthesized from phosphatidylethanolamine or phosphatidylcholine through the exchange of the nitrogen base with free serine. PtdSer concentration in the nervous tissue membranes varies with age, brain areas, cells, and subcellular components. At least two serine base exchange enzymes isoforms are present in brain, and their biochemical properties and regulation are still largely unknown because their activities vary with cell type and/or subcellular fraction, developmental stage, and differentiation. These peculiarities may explain the apparent contrasting reports. PtdSer cellular levels also depend on its decarboxylation to phosphatidylethanolamine and conversion to lysoPtdSer by phospholipases. Several aspects of brain PtdSer metabolism and functions seem related to the high polyunsaturated fatty acids content, particularly docosahexaenoic acid (DHA).

Phosphatidylserine base exchange phosphatidylserine decarboxylase docosahexaenoic acid cell signaling apoptosis brain 

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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Rita Mozzi
    • 1
  • Sandra Buratta
    • 1
  • Gianfrancesco Goracci
    • 1
    Email author
  1. 1.Department of Internal Medicine, Division of BiochemistryUniversity of PerugiaPerugiaItaly

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