Heart Failure Reviews

, Volume 8, Issue 1, pp 107–115

The Nitric Oxide-Endothelin-1 Connection

Article

Abstract

Nitric oxide (NO) and endothelin-1 (ET-1) are endothelium-derived mediators that play important roles in vascular homeostasis. This review is focused on the role and reciprocal interactions between NO and ET-1 in health and diseases associated with endothelium dysfunction. We will also discuss the clinical significance of NO donors and drugs that antagonize ET receptors.

nitric oxide endothelin vascular tone cardiovascular system receptor antagonist heart failure 

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© Kluwer Academic Publishers 2003

Authors and Affiliations

  1. 1.Department of Integrative Biology and PharmacologyUniversity of Texas-HoustonUSA

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