Breast Cancer Research and Treatment

, Volume 78, Issue 1, pp 1–6 | Cite as

Estradiol Promotes Growth and Angiogenesis in Polyoma Middle T Transgenic Mouse Mammary Tumor Explants

  • Charlotta Dabrosin
  • Kay Palmer
  • William J. Muller
  • Jack Gauldie


Estrogen is important for breast carcinogenesis and the majority of breast cancers maintain hormone dependency. Estrogen has the ability to stimulate both breast epithelial cell growth and angiogenesis, and a well-characterized in vivo cancer model where these functional interactions can be studied is lacking. We demonstrate estrogen dependent angiogenesis, growth in vivo, and proliferation in vitro, in explants from polyoma middle T transgenic mouse mammary tumors. Thus, in addition to genetic similarities, this model also exerts a sex hormone, and angiogenic phenotype similar to human breast cancer. This immune-competent animal model offers the opportunity to study molecular events in estrogen dependent breast cancer.

breast cancer CD31 Matrigel MMTV sex steroids 


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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Charlotta Dabrosin
    • 1
  • Kay Palmer
    • 1
  • William J. Muller
    • 1
  • Jack Gauldie
    • 1
  1. 1.Department of Pathology and Molecular Medicine and Centre for Gene TherapeuticsMcMaster UniversityHamiltonCanada

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