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Tropical Animal Health and Production

, Volume 35, Issue 1, pp 17–25 | Cite as

Evolution of High-level, Multiple Anthelmintic Resistance on a Sheep Farm in Malaysia

  • P. Chandrawathani
  • P.J. Waller
  • M. Adnan
  • J. Höglund
Article

Abstract

Anthelmintic resistance in nematode parasites of sheep and goats on a government farm in north Malaysia was monitored over a 3-year period (1997–2000). The faecal egg count reduction test (FECRT) was conducted on young sheep at the beginning and end of this period. Changes in management, designed to reduce the selection pressure for the development of anthelmintic resistance, were also implemented during this time. By far the most important parasite problem was Haemonchus contortus. In 1997, this nematode was found to be resistant to levamisole, with suspected resistance to closantel and moxidectin. However, when the FECRT was repeated 3 years later, its resistance status had become much more severe, with resistance to benzimidazole, levamisole and ivermectin, and suspected resistance to moxidectin. This rapid evolution to multiple anthelmintic resistance is a major concern that needs to be arrested. There is an urgent need to evaluate other control strategies that incorporate livestock management, the `smart' use of drugs and non-chemotherapeutic approaches, such as biological control agents.

anthelmintic control drug resistance Haemonchus contortus helminth nematode 

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REFERENCES

  1. Anonymous, 1989. Anthelmintic resistance, Report of a working party for the Animal Health Committee of the Standing Committee on Agriculture (SCA), (SCA Technical Report series no. 28, Canberra, Australia)Google Scholar
  2. Barger, I.A., Siale, K., Banks, D.J.D. and Le Jambre, L.F., 1994. Rotational grazing for control of gastrointestinal nematodes of goats in a wet tropical environment. Veterinary Parasitology, 53, 109-116Google Scholar
  3. Chandrawathani, P., Parameswaran, S. and Mohd, A.M., 1994. Antiparasitic drugs used in selected sheep and goat farms in West Malaysia. Veterinary Journal of Malaysia, 6, 61-64Google Scholar
  4. Chandrawathani, P., Jamnah, O. and Rajamanickam, C., 1995. Testing potential control programmes for helminthiasis in sheep on open pasture. In: Proceedings of the 17th Malaysian Society of Animal Production Annual Conference, Penang, Malaysia, 112-113Google Scholar
  5. Chandrawathani, P., Adnan, M., Maria, J., Hong, K.S. and Wan Zahari, M., 1996a. Uptake of fenbendazole by sheep fed with mediated urea molasses blocks. In: Proceedings of the Eighth Veterinary Association Scientific Congress, Ipoh, 53-54Google Scholar
  6. Chandrawathani, P., Adnan, M., Jamnah, O. and Rajamanickam, C., 1996b. The efficacy of netobimin and levamisole against benzimidazole resistant strains of Haemonchus contortus in goats in Malaysia. Journal of Bioscience, 7, 83-85Google Scholar
  7. Chandrawathani, P., Adnan, M. and Waller, P.J., 1999a. Anthelmintic resistance in sheep and goat farms on Peninsular Malaysia. Veterinary Parasitology, 82, 305-310Google Scholar
  8. Chandrawathani, P., Jamnah, O., Waller, P.J. and Höglund, J., 1999b. Biological control of small ruminant nematode parasites in the tropics. In: Proceedings of the 17th International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), CopenhagenGoogle Scholar
  9. Chandrawathani, P., Adnan, M. and Zaini, C.M., 2000. Preliminary studies on neem (Azadirachta indica) as an alternative anthelmintic for sheep. In: Proceedings of the 12th Veterinary Association of Malaysia Scientific Congress, Kuantan, 126-127Google Scholar
  10. Coles, G.C., Bauer, C., Borgsteede, F.H.M., Geerts, S., Klei, T.R., Taylor, M.A. and Waller, P.J., 1992. World Association for the Advancement of Veterinary Parasitology (WAAVP) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Veterinary Parasitology, 44, 35-44Google Scholar
  11. Dorny, P., Clarebout, E., Vercruysse, J., Jalila, A. and Sani, R., 1993. Benzimidazole resistance of Haemonchus contortus in goats in Malaysia. The Veterinary Record, 133, 423-424Google Scholar
  12. Dorny, P., Clarebout, E., Vercruysse, J., Sani, R. and Jalila, A., 1994a. Anthelmintic resistance in goats in Peninsular Malaysia. Veterinary Parasitology, 55, 327-342Google Scholar
  13. Dorny, P., Vercruysse, J., Jalila, A., Sani, R. and Symoens, C., 1994b. Control of haemonchosis in Malaysian goats with closantel. Veterinary Parasitology, 53, 233-241Google Scholar
  14. Hennessy, D.R., 1997. Modifying the formulation or delivery mechanism to increase the activity of anthelmintic compounds. Veterinary Parasitology, 72, 367-390Google Scholar
  15. McKellar, Q.A. and Benchaoui, H.A., 1996. Avermectins and milbemycins. Journal of Veterinary Parasitology, 19, 331-351Google Scholar
  16. Pandey, V.S. and Sivaraj, S., 1994. Anthelmintic resistance in Haemonchus contortus from sheep in Malaysia. Veterinary Parasitology, 53, 67-74Google Scholar
  17. Prichard, R.K., 1978. Sheep anthelmintics. In: A.D. Donald, W.H. Southcott and J.K. Dineen (eds), The Epidemiology and Control of Gastrointestinal Parasites of Sheep in Australia, Academic Press, Sydney, Australia, 75-107Google Scholar
  18. Sani, R.A. and Rajamanickam, C., 1990. Gastrointestinal parasitism in small ruminants. In: Proceedings of a Workshop on Research Methodologies, Sumatra, Indonesia, 197-201Google Scholar
  19. Sani, R.A., Panandam, J., Ben-Ghishir, M.A., Sharifah-Norhaimi, M.S. and Ibrahim, J., 2000. Selection of sheep for resistance to worms. In: Proceedings of the 22nd MSAP Annual Conference, 2000, Kota Kinabalu, Sabah, 235-236Google Scholar
  20. Sivaraj, S., Dorny, P., Verccruysse, J. and Pandey, V.S., 1994. Multiple and multigeneric resistance on a sheep farm in Malaysia. Veterinary Parasitology, 55, 159-165Google Scholar
  21. Waller, P.J., 1997. Anthelmintic resistance. Veterinary Parasitology, 72, 391-412Google Scholar

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • P. Chandrawathani
    • 1
  • P.J. Waller
    • 2
  • M. Adnan
    • 1
  • J. Höglund
    • 3
  1. 1.Veterinary Research InstituteIpohMalaysia
  2. 2.National Veterinary InstituteSWEPARUppsalaSweden
  3. 3.SWEPAR, Swedish University of Agricultural SciencesUppsalaSweden

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