Journal of Nanoparticle Research

, Volume 4, Issue 5, pp 395–403

Imaging {Au0-PAMAM} Gold-dendrimer Nanocomposites in Cells

  • Anna Bielinska
  • Jonathan D. Eichman
  • Inhan Lee
  • James R. BakerJr.
  • Lajos Balogh
Article

Abstract

Dendrimer nanocomposites (DNC) are hybrid nanoparticles formed by the dispersion and immobilization of guest atoms or small clusters in dendritic polymer matrices. They have a great potential in biomedical applications due to their controlled composition, predetermined size, shape and variable surface functionalities. In this work, d=5–25 nm spherical nanoparticles composed of gold and poly(amidoamine) (PAMAM) dendrimers have been selected to demonstrate this nanoparticle based concept. {Au(0)n-PAMAM} gold dendrimer nanocomposites with a well-defined size were synthesized and imaged by transmission electron microscopy both in vitro and in vivo. DNC have also the potential to be used for imaging and drug delivery vehicles either by utilizing bioactive guests or through the incorporation of radioactive isotopes, such as Au-198.

nanocomposites dendrimers imaging gene transfer drug delivery gold/dendrimer composite 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Anna Bielinska
    • 1
  • Jonathan D. Eichman
    • 1
  • Inhan Lee
    • 1
  • James R. BakerJr.
    • 1
  • Lajos Balogh
    • 1
  1. 1.Center for Biologic NanotechnologyUniversity of MichiganAnn ArborUSA

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