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Neurochemical Research

, Volume 28, Issue 1, pp 15–27 | Cite as

p53-Dependent Cell Death Signaling in Neurons

  • Richard S. Morrison
  • Yoshito Kinoshita
  • Mark D. Johnson
  • Weiqun Guo
  • Gwenn A. Garden
Article

Abstract

The p53 tumor suppressor gene is a sequence-specific transcription factor that activates the expression of genes engaged in promoting growth arrest or cell death in response to multiple forms of cellular stress. p53 expression is elevated in damaged neurons in acute models of injury such as ischemia and epilepsy and in brain tissue samples derived from animal models and patients with chronic neurodegenerative diseases. p53 deficiency or p53 inhibition protects neurons from a wide variety of acute toxic insults. Signal transduction pathways associated with p53-induced neuronal cell death are being characterized, suggesting that intervention may prove effective in maintaining neuronal viability and restoring function following neural injury and disease.

Apoptosis cell death neurons/neurodegeneration p53 caspase Bcl-2 family 

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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Richard S. Morrison
    • 1
  • Yoshito Kinoshita
    • 1
  • Mark D. Johnson
    • 1
  • Weiqun Guo
    • 1
  • Gwenn A. Garden
    • 1
  1. 1.Department of Neurological Surgery and Department of NeurologyUniversity of Washington School of Medicine, SeattleWashington

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