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Behavior Genetics

, Volume 29, Issue 6, pp 409–421 | Cite as

A Twin Study of Drinking and Smoking Onset and Latencies from First Use to Regular Use

  • M. C. Stallings
  • J. K. Hewitt
  • T. Beresford
  • A. C. Heath
  • L. J. Eaves
Article

Abstract

The early onset of alcohol and tobacco use has been associated with increased risk for later substance abuse and dependence problems. This study investigated genetic and environmental influences on age at onset of alcohol and tobacco use by examining twin resemblance for several retrospectively reported onset milestones including age at first use, age at first alcohol intoxication experience, and age at regular use. In addition, we also examined the latency between age at first use and age at regular use of tobacco and alcohol. The subjects were a volunteer sample of older adult twins 50 to 96 years of age. MZ twin correlations for age at first alcohol use and age at first tobacco use were .57 and .44, respectively, compared to .45 and .37 for DZ same-sex twins. MZ twins correlated .30 and .26 for the latencies between first use and regular use of alcohol and of tobacco, while DZ correlations were −.01 and .05, respectively. Biometrical model-fitting results confirmed that familial resemblance for age at first use for both alcohol and tobacco was largely the result of shared environmental factors, while the latencies between first use and regular patterns of use were more genetically influenced. These findings add to a growing body of literature suggesting that initiation of substance use is influenced primarily by environmental rather than genetic factors.

Twin study drinking onset smoking onset latency from first to regular use substance abuse genetics 

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REFERENCES

  1. Akaike, H. (1970). Statistical predictor identification. Ann. Inst. Stat. Math. 21:243-247.CrossRefGoogle Scholar
  2. Barnes, G. M., Welte, J. W., and Dintcheff, B. (1992). Alcohol misuse among college students and other young adults: Findings from a general population study in New York State. Int. J. Addict. 27:917-934.CrossRefGoogle Scholar
  3. Blom, G. (1958). Statistical Estimates and Transformed Beta Variables, John Wiley & Sons, New York.Google Scholar
  4. Brewer, W. F. (1988). Memory for randomly sampled autobiographical events. In Neisser, U., and Winograd, E. (eds.), Remembering Reconsidered: Ecological and Traditional Approaches to the Study of Memory, Cambridge University Press, New York, pp. 21-90.CrossRefGoogle Scholar
  5. Carmelli, D., Swan, G. E., Robinette, D., and Fabsitz, R. (1990). Heritability of substance use in the NAS-NRC Twin Registry. Acta Genet. Med. Gemellol. 39:91-98.CrossRefGoogle Scholar
  6. Carmelli, D., Swan, G. E., Robinette, D., and Fabsitz, R. (1992). Genetic influence on smoking: A study of male twins. N. Engl. J. Med. 327:829-833.CrossRefGoogle Scholar
  7. Cederlöf, R., Friberg, L., Jonsson, E., and Kaij, L. (1961). Studies on similarity diagnosis in twins with the aid of mailed questionnaires. Acta Genet. Stat. Med. 11:338-362.PubMedGoogle Scholar
  8. Chou, S. P., and Pickering, R. P. (1992). Early onset of drinking as a risk factor for lifetime alcohol-related problems. Br. J. Addict. 87:1199-1204.CrossRefGoogle Scholar
  9. Clapper, R. L., Buka, S. L., Goldfield, E. C., Lipsitt, L. L., and Tsuang, M. T. (1995). Adolescent problem behaviors as predictors of adult alcohol diagnoses. Int. J. Addict. 30:507-523.CrossRefGoogle Scholar
  10. Clifford, C. A., Hopper, J. L., Fulker, D. W., and Murray, R. M. (1984). A genetic and environmental analysis of a twin family study of alcohol use, anxiety and depression. Genet. Epidemiol. 1:63-79.CrossRefGoogle Scholar
  11. Cloninger, C. R., Bohman, M., and Sigvardsson, S. (1981). Inheritance of alcohol abuse: Cross-fostering analysis of adopted men. Arch. Gen. Psychiatry 38:861-867.CrossRefGoogle Scholar
  12. Cloninger, C. R., Reich, T., Sigvardsson, S., Von Knorring, A. L., and Bohman, M. (1988). Effects changes in alcohol use between generations on the inheritance of alcohol abuse. In Rose, R. M., and Bennett, J. E., (eds.), Alcoholism: Origins and Outcomes, Raven Press, New York, pp. 49-74.Google Scholar
  13. Falconer, D. S. (1989). Introduction to Quantitative Genetics, 3rd ed., John Wiley & Sons, New York.Google Scholar
  14. Fergusson, D. M., Lynskey, M. T., and Horwood, L. J. (1994). Childhood exposure to alcohol and adolescent drinking patterns. Addiction 89:1007-1016.CrossRefGoogle Scholar
  15. Gabrielli, W. F., and Plomin, R. (1985). Drinking behavior in the Colorado adoptee and twin sample. J.Stud.Alcohol 46:24-31.CrossRefGoogle Scholar
  16. Gonzalez, G. M. (1989). Early onset of drinking as a predictor of alcohol consumption and alcohol-related problems in college. J. Drug Educ. 19:225-230.CrossRefGoogle Scholar
  17. Grant, B. F., and Dawson, D. A. (1997). Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: Results from the National Longitudinal Alcohol Epidemiologic Survey. J. Subst. Abuse 9:103-110.CrossRefGoogle Scholar
  18. Han, C., McGue, M. K., and Iacono, W. G. (1999). Lifetime tobacco, alcohol and other substance use in adolescent Minnesota twins: Univariate and multivariate behavioral genetic analyses. Addiction 94:981-993.CrossRefGoogle Scholar
  19. Hawkins, J. D., Catalano, R. F., and Miller, J. Y. (1992). Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood: Implications for substance abuse prevention. Psychol. Bull. 112:64-105.CrossRefGoogle Scholar
  20. Hawkins, J. D., Graham, J. W., Maguin, E., Abbott, R., Hill, K. G., and Catalano, R. F. (1997). Exploring the effects of age of alcohol use initiation and psychosocial risk factors on subsequent alcohol misuse. J. Stud. Alcohol 58:280-290.CrossRefGoogle Scholar
  21. Hays, R. D., Stacy, A. W., Widaman, K. F., DiMatteo, M. R., and Downey, R. (1986). Multistage path models of adolescent alcohol and drug use: A reanalysis. J. Drug Issues 16:357-369.CrossRefGoogle Scholar
  22. Hays, R. D., Widaman, K. F., DiMatteo, M. R., and Stacy, A. W. (1987). Structural equation models of current drug use: Are appropriate models so simple(x)? J.Pers. Soc. Psychol. 52:134-144.CrossRefGoogle Scholar
  23. Heath A. C. (1999). Genetic influences on drinking behavior in humans. In Begleiter, H., and Kissin, B. (eds.), Alcohol and Alcoholism, Vol. 1, Oxford University Press, New York (in press).Google Scholar
  24. Heath, A. C., and Madden, P. A. F. (1995). Genetic influences on smoking behavior. In Turner, J. R., Cardon, L. R., and Hewitt, J. K. (eds.), Behavior Genetic Approaches in Behavioral Medicine, Plenum, New York, pp. 45-66.CrossRefGoogle Scholar
  25. Heath, A. C., and Martin, N. G. (1988). Teenage alcohol use in the Australian Twin Register: Genetic and social determinants of starting to drink. Alcohol. Clin. Exp. Res. 12:735-741.CrossRefGoogle Scholar
  26. Heath, A. C., and Martin, N. G. (1993). Genetic models for the natural history of smoking: Evidence for a genetic influence on smoking persistence. Addict. Behav. 18:19-34.CrossRefGoogle Scholar
  27. Heath, A. C., Jardine, R., and Martin, N. G. (1989). Interactive effects of genotype and social environment on alcohol consumption in female twins. J. Stud. Alcohol 50:38-48.CrossRefGoogle Scholar
  28. Heath, A. C., Meyer, J., Eaves, L. J., and Martin, N. G. (1991a). The inheritance of alcohol consumption patterns in a general population twin sample: I. Multidimensional scaling of quantity/frequency data. J. Stud. Alcohol 52:345-352.CrossRefGoogle Scholar
  29. Heath, A. C., Meyer, J., Eaves, L. J., and Martin, N. G. (1991b). The inheritance of alcohol consumption patterns in a general population twin sample: II. Determinants of consumption frequency and quantity consumed. J. Stud. Alcohol 52:425-433.CrossRefGoogle Scholar
  30. Heath, A. C., Cates, R., Martin, N. G., Meyer, J., Hewitt, J. K., Neale, M. C., and Eaves, L. J. (1993). Genetic contribution to risk of smoking initiation: Comparisons across birth cohorts and across cultures. J. Subst. Abuse 5:221-246.CrossRefGoogle Scholar
  31. Heath, A. C., Bucholz, K. K., Madden, P. A. F., Dinwiddie, S. H., Slutske, W. S., Beirut, L. J., Stratham, D. J., Dunne, M. P., Whitfield, J. B., and Martin, N. G. (1997a). Genetic and environmental contributions to alcohol dependence risk in a national twin sample: Consistency of findings in men and women. Psychol. Med. 27:1381-1396.CrossRefGoogle Scholar
  32. Heath, A. C., Slutske, W. S., and Madden, P. A. F. (1997b). Gender differences in the genetic contribution to alcoholism risk and to alcohol consumption patterns. In Wilsnack, R. W., and Wilsnack, S. C. (eds.), Gender and Alcohol, Rutgers University, NJ, pp. 114-149.Google Scholar
  33. Heath, A. C., Madden, P. A. F., and Martin, N. G. (1998). Statistical methods in genetic research on smoking. Stat. Methods Med. Res. 7:165-186.CrossRefGoogle Scholar
  34. Henry, B., Moffitt, T. E., Caspi, A., Langley, J., and Silva, P. A. (1994). On the “remembrance of things past”: A longitudinal evaluation of the retrospective method. Psychol. Assess. 52:134-144.Google Scholar
  35. Jessor, R., and Jessor, S. L. (1975). Adolescent development and the onset of drinking: A longitudinal study. J. Stud. Alcohol 36:27-51.CrossRefGoogle Scholar
  36. Jessor, R., and Jessor, S. L. (1977). Problem Behavior and Psychosocial Development: A Longitudinal Study, Academic Press, New York.Google Scholar
  37. Jessor, R., Donovan, J. E., and Costa, F. M. (1991). Beyond Adolescence. Problem Behavior and Young Adult Development, Cambridge University Press, Cambridge, England.Google Scholar
  38. Kaij, L. (1960). Alcoholism in Twins, Almqvist & Wiksell International, Stockholm.Google Scholar
  39. Kandel, D. (1975). Stages in adolescent involvement in drug use. Science 190:912-914.CrossRefGoogle Scholar
  40. Kandel, D., and Faust, R. (1975). Sequence and stages in patterns of adolescent drug use. Arch. Gen. Psychiatry 32:923-932.CrossRefGoogle Scholar
  41. Kandel, D., and Raveis, V. H. (1989). Cessation of illicit drug use in young adulthood. Arch. Gen. Psychiatry 46:109-116.CrossRefGoogle Scholar
  42. Kandel, D., Yamaguchi, K., and Chen, K. (1992). Stages of progression in drug involvement from adolescence to adulthood: Further evidence for the gateway theory. J. Stud. Alcohol 53:447-457.CrossRefGoogle Scholar
  43. Kaprio, J., Koskenvuo, M., Langinvainio, H., Romanov, K., Sarna, S., and Rose, R. J. (1987). Genetic influences on use and abuse of alcohol: A study of 5638 adult Finnish twin brothers. Alcohol. Clin. Exp. Res. 11:349-356.CrossRefGoogle Scholar
  44. Kasriel, J., and Eaves, L. J. (1976). The zygosity of twins: Further evidence on the agreement between diagnosis by blood groups and written questionnaires J. Biosoc. Sci. 8:263-266.CrossRefGoogle Scholar
  45. Kendler, K. S., Heath, A. C., Neale, M. C., Kessler, R. C., and Eaves, L. J. (1992). A population-based twin study of alcoholism in women. JAMA 268:1877-1881.CrossRefGoogle Scholar
  46. Koopmans, J. R., and Boomsma, D. I. (1996). Familial resemblances in alcohol use: Genetic or cultural transmission? J. Stud. Alcohol 57:19-28.CrossRefGoogle Scholar
  47. Labouvie, E. (1996). Maturing out of substance use: Selection and self-correction. J. Drug Issues 26:455-474.CrossRefGoogle Scholar
  48. Labouvie, E., Bates, M. E., and Pandina, R. J. (1997). Age of first use: Its reliability and predictive utility. J. Stud. Alcohol 58:638-643.CrossRefGoogle Scholar
  49. McGue, M. (1993). Genes, environment and the etiology of alcoholism. In Development of Alcohol-Related Problems in High-Risk Youth: Establishing Linkages Across Biogenetic and Psychosocial Domains, National Institute on Alcoholism and Alcohol Abuse, Research Monograph, Rockville, MD.Google Scholar
  50. McGue, M., Pickens, R. W., and Svikis, D. S. (1992). Sex and age effects on the inheritance of alcohol problems: A twin study. J. Abnorm. Psychol. 101:3-17.CrossRefGoogle Scholar
  51. Meyer, J., Heath, A. C., and Eaves, L. J. (1992). Using multidimensional scaling on data from pairs of relatives to explore the dimensionality of categorical multifactorial traits. Genet. Epidemiol. 9:87-107.CrossRefGoogle Scholar
  52. Neale, M. C. (1998). Mx: Statistical Modeling, 5th ed., Department of Psychiatry, Virginia Commonwealth University, Richmond.Google Scholar
  53. Neale, M. C., and Cardon, L. R. (1992). Methodology for Genetic Studies of Twins and Families, Plenum, New York.CrossRefGoogle Scholar
  54. Newcomb, M. D., and Bentler, P. M. (1988). Consequence of Adolescent Drug Use, Sage, Newbury Park, CA.Google Scholar
  55. Partanen, J., Bruun, K., and Markkanen, T. (1966). Inheritance of Drinking Behavior: A Study on Intelligence, Personality, and Use of Alcohol of Adult Twins, Finnish Foundation for Alcohol Studies, Helsinki, Vol. 14.Google Scholar
  56. Pedersen, W., and Skrondal, A. (1998). Alcohol consumption debut: Predictions and consequences. J. Stud. Alcohol 59:32-42.CrossRefGoogle Scholar
  57. Pickens, R. W., Svikis, D. S., McGue, M., Lykken, D. T., Heston, L. L., and Clayton, P. J. (1991). Heterogeneity in the inheritance or alcoholism: A study of male and female twins. Arch. Gen. Psychiatry 48:19-28.CrossRefGoogle Scholar
  58. Pollock, V. E. (1992). Meta-analysis of subjective sensitivity to alcohol in sons of alcoholics. Am. J. Psychiatry 149:1534-1538.CrossRefGoogle Scholar
  59. Prescott, C. A., and Kendler, K: S. (1999). Age at first drink and risk for alcoholism: A noncausal association. Alcohol. Clin. Exp. Res. 23:101-107.PubMedGoogle Scholar
  60. Prescott, C. A., Hewitt, J. K., Truett, K. R., Heath, A. C., Neale, M. C., and Eaves, L. J. (1994a). Environmental and genetic influences on alcohol use in a volunteer sample of older twins. J. Stud. Alcohol 55:18-33.CrossRefGoogle Scholar
  61. Prescott, C. A., Hewitt, J. K., Truett, K. R., Heath, A. C., Neale, M. C., and Eaves, L. J. (1994b). Genetic and environmental influences on lifetime alcohol-related problems in a volunteer sample of older twins. J. Stud. Alcohol 55:184-202.CrossRefGoogle Scholar
  62. Robins, L. N., and Przybeck, T. R. (1985). Age of onset of drug use as a factor in drug and other disorders. In Jones, C. L., and Battjes, R. L. (eds.), Etiology of Drug Abuse: Implications for Prevention, No. ADM 85-1335, Government Printing Office, Washington, DC, pp. 178-192.Google Scholar
  63. Robins, L. N., Schoenberg, S. P., Holmes, S. J., Ratcliff, K. S., Benham, A., and Works, J. (1985). Early home environment and retrospective recall: A test for concordance between siblings with and without psychiatric disorders. Am. J. Orthopsychiatry 55:27-41.CrossRefGoogle Scholar
  64. Rose, R. J., Kaprio, J., Winter, T., Koskenvuo, M., and Viken, R. (1999). Familial and socioregional environmental effects on abstinence from alcohol at age sixteen. J. Stud. Alcohol Suppl. 13:63-74.CrossRefGoogle Scholar
  65. Schuckit, M. A. (1980). Alcoholism and genetics: Possible biological mechanisms. Biol. Psychiatry 15:437-447.PubMedGoogle Scholar
  66. Schuckit, M. A. (1985). Ethanol-induced changes in body-sway in men at high alcoholism risk. Arch. Gen. Psychiatry 42:375-379.CrossRefGoogle Scholar
  67. Schuckit, M. A. (1994). Low level of response to alcohol as a predictor of future alcoholism. Am. J. Psychiatry 151:184-189.CrossRefGoogle Scholar
  68. Schuckit, M. A., and Smith, T. L. (1997). Assessing the risk for alcoholism among sons of alcoholics. J. Stud. Alcohol 58:141-145.CrossRefGoogle Scholar
  69. True, W. R., Heath, A. C., Scherrer, J. F., Waterman B., Goldberg, J., Lin, N., Eisen, S. A., Lyons, M. J., and Tsuang, M. (1997). Genetic and environmental contributions to smoking. Addiction 92:1277-1287.CrossRefGoogle Scholar
  70. True, W. R., Xian, H., Scherrer, J. F., Madden, P. A. F., Bucholz, K. K., Heath, A. C., Eisen, S. A., Lyons, M. J., Goldberg, J., and Tsuang, M. (1999). Common genetic vulnerability for nicotine and alcohol dependence in men. Arch. Gen. Psychiatry 56:655-661.CrossRefGoogle Scholar
  71. Welte, J. W., and Barnes, G. M. (1985). Alcohol: The gateway to other drug use among secondary-school students. J. Youth Adolesc. 14:487-498.CrossRefGoogle Scholar
  72. Williams, C. L., Perry, C. L., Dudovitz, B., Veblen-Mortenson, S., Anstine, P. S., Komro, K. A., and Tommey, T. L. (1995). A home-based prevention program for sixth-grade alcohol use: Results from Project Northland. J. Prim. Prev. 16:125-147.CrossRefGoogle Scholar
  73. Yamaguchi, K., and Kandel, D. B. (1984a) Patterns of drug use from adolescence to young adulthood: II. Sequences of progression. Am. J. Public Health 74:668-672.CrossRefGoogle Scholar
  74. Yamaguchi, K., and Kandel, D. B. (1984b). Patterns of drug use from adolescence to young adulthood: III. Predictors of progression. Am. J. Public Health 74:673-681.CrossRefGoogle Scholar
  75. Yu, J., and Williford, W. R. (1992). The age of alcohol onset and alcohol, cigarette, and marijuana use patterns: An analysis of drug use progression of young adults in New York State: Int. J. Addict. 27:1313-1323.CrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • M. C. Stallings
    • 1
  • J. K. Hewitt
    • 1
  • T. Beresford
    • 2
  • A. C. Heath
    • 3
  • L. J. Eaves
    • 4
  1. 1.Institute for Behavioral GeneticsUniversity of ColoradoBoulder
  2. 2.Department of PsychiatryDepartment of Veterans AffairsDenver
  3. 3.Department of PsychiatryWashington University School of MedicineSt. Louis
  4. 4.Department of Human GeneticsMedical College of VirginiaRichmond

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