Biotechnology Letters

, Volume 24, Issue 24, pp 2093–2098

Intracellular drug delivery using poly(d,l-lactide-co-glycolide) nano- particles derivatized with a peptide from a transcriptional activator protein of HIV-1

  • Yoon Sung Nam
  • Ju Young Park
  • Sang-Hoon Han
  • Ih-Seop Chang
Article

Abstract

Biodegradable poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles were derivatized with Tat49−57 peptide, which is the protein transduction domain from the transcriptional activator Tat protein of human immunodeficiency virus type-1 (HIV-1). The Tat49−57 peptide-modified PLGA nanoparticles, with a mean diameter of ca. 238 nm, was effectively adsorbed on to the membrane of HaCaT cells and delivered into the nuclei without cytotoxicity.

biodegradable polymer conjugates nanoparticles protein transduction domain (PTD) Tat peptide 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Yoon Sung Nam
    • 1
  • Ju Young Park
    • 1
  • Sang-Hoon Han
    • 1
  • Ih-Seop Chang
    • 1
  1. 1.Amore Pacific R&D CenterGiheung-eup, Yongin-si, Gyounggi-doSouth Korea

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